Treatment goals for Head & Neck cancers can be indicated as: 1) Eradication of the tumor (ablative surgery or XRT, combinations), 2) Restoration of the anatomy (reconstructive surgery), 3) Rehabilitation of the function. Of course, the main goals are to increase survi [....] » Read More
Drug metabolism is crucial in any functioning of a drug, particularly in drugs for cancer treatment. Several drugs do not function in human body in their original state unless metabolised to its required functioning metabolite to affect its target organ/site or tissue. Drug metab [....] » Read More
Poly(lactic-co-glycolic acid) (PLGA) nanoparticle has proven extremely useful for drug delivery, thanks to its high biocompatibility, biodegradability, and toxicologically safe degradation products. This talk will emphasize the use of nanosized (~140 nm mean diameter) PLGA loaded [....] » Read More
Biosensor technology represents an attractive strategy for the detection and monitoring of biomarkers for disease states within the context of precision medicine. This approach offers the possibility for biomarker assay via incorporation into an automated robotic system to proces [....] » Read More
Background: Current screening methods, have limitations in the diagnosis and prognosis of prostate cancer. This study examined whether mRNA-genomic biomarkers can improve screening and monitoring of prostate cancer. Methods: We identified a panel of 25 prostate cancer-related [....] » Read More
On short arm of human chromosome 3, a region 3p21, which is deleted in a variety of tumors, harbors a cluster of putative tumor suppressor genes (TSGs). One of the TSG candidates, BLU, coding for a zinc protein ZMYND10 has initially recognized as a fragment lost in lung cancers. [....] » Read More
Background: Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the epigenetic process of la [....] » Read More
Objective: Dissecting the cellular/molecular/genetic regulatory biochemical signaling networks: Autophagy/Toll-like Receptors/Wnt-Frizzled in inflammatory “gastrohepatic disease-web” primarily hepatocellular/colorectal/cholangiocarcinomas is essential for diminishing [....] » Read More
Modern medical methods of treatment allow in some cases to prevent the development of pathological processes in the human body. It is known that the effectiveness of such therapeutic effects is largely determined by the possibility of diagnosing the disease at the initial stages [....] » Read More
Febrile neutropenia (FEN) is the most common life-threatening complication of childhood cancer. Early initiation of broad-spectrum intravenous antibiotics to patients has reduced the mortality of FEN below 5%. Studies have reported viral infections to constitute 35 to 55% of FEN [....] » Read More
Background Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide.1 It is the second most common cancer diagnosed in women and third most in men. In women, incidence and mortality are approximately 25% lower than in [....] » Read More
Breast cancer is the most prevalent malignancy in women worldwide and remains a leading cause of cancer-related mortality. Immune system controls tumor progression but is often suppressed in breast cancer. Dendritic cells (DCs), essential for linking innate and adaptive immunity, [....] » Read More
Each year, a high number of new cases of thyroid cancer are identified. Although this disease has a good prognosis, it is often immediately metastatic, which requires removal of the thyroid body, followed by iratherapy (administration of iodine 131) in order to eradicate the vari [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More
Introduction: The integration of breast cancer screening into daily clinical care leads to an early diagnosis and reduces its mortality. However, many women are reluctant and do not get tested. Objective To study the factors associated with the practice of breast cancer scre [....] » Read More
Cancers are genetic and epigenetic diseases in which cells divide and grow in uncontrolled ways due to mutations or molecular alterations. Gene fusion phenomena is recurrent in cancer cells. One of the most common cancers is breast cancer, representing worldwide public health con [....] » Read More
Background: We developed the laparoscopic and endoscopic cooperative surgery (LECS) technique, which combines non-exposed wall-inversion surgery (NEWS) and sentinel node navigation surgery (SNNS) to treat early gastric cancer (EGC). It is a technique which preserves organ functio [....] » Read More
Background: We developed the laparoscopic and endoscopic cooperative surgery (LECS) technique, which combines non-exposed wall-inversion surgery (NEWS) and sentinel node navigation surgery (SNNS) to treat early gastric cancer (EGC). It is a technique which preserves organ functio [....] » Read More
Introduction: HR+/HER2-negative Early Breast Cancer (EBC) is treated with curative intent, but managing locoregional and distant recurrences remains a significant challenge. The lack of a standard risk-identification approach leads to varied assessments across centers. Developi [....] » Read More
Artificial Intelligence (AI) has emerged as a transformative force in oncology, offering unparalleled potential to revolutionize cancer care. By leveraging advanced algorithms and machine learning models, AI enhances every phase of the cancer care continuum—from early detec [....] » Read More
MHC class I complexes can present antigenic peptides that have a sequence produced by post-translational mechanisms such as peptide splicing. Some examples of tumour-associated spliced epitopes have been investigated for their immunogenicity in the context of cancer so far. We de [....] » Read More
About 2 in 5 Canadians are expected to be diagnosed with cancer in their lifetime and 1 in 4 die of it. I would discuss interesting updates of advances in cancer research. Biomarker assays have become routine for some cancers. Circulating tumor cells/cell-free deoxyribonucleic [....] » Read More
RNA binding proteins (RBPs) are regulators of RNA metabolism and influence protein expression in various physiologic and pathologic conditions through regulation of RNA splicing, stability and translation. Several studies have demonstrated that RBPs play a role in cancer developm [....] » Read More
Numerous cancer-related mechanisms are reported daily, yet a universal theory for eradicating all cancers remains elusive. Fortunately, recent advances in big data and AI have identified noncoding RNAs as central players in all cancers, challenging the conventional protein-centri [....] » Read More
All studies were performed on a 3 T whole-body MRI system (MAGNETOM Prisma, Siemens Healthineers, Erlangen, Germany) using a 16-channel surface coil (Zhongzhi Medical, Jiangsu). Firstly, we evaluated the thyroid nodule image quality between two diffusion weighted imaging (DWI) te [....] » Read More
Bromodomain and extra-terminal (BET) family members, including BRD2, BRD3, BRD4 and BRDT, function as critical readers of acetylated histones and globally activate oncogene expression. These proteins have emerged as attractive epigenetic targets for cancer therapy, with more th [....] » Read More
The molecular weights of amino acids are time values where integer and decimal part have separate identity but interrelated. Derived from the factor 14.0267 e.g. 119.1197(Thr) – 105.0930(Ser) = 14.0267 = 131.1736(Leu) – 117.1469(Val), the formula T(time) = 0.0019*M(in [....] » Read More
Glioblastoma Multiforme G IV primary malignant Brain tumor medications such as Radiation, Surgery, Gene therapy, Chemotherapy and Ayurveda which are not very much successful with clinical studies. However, the trials are being made towards the various cancers’ successful tr [....] » Read More
Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the oral cavity. SCC is a major health problem for the world. Based on GLOBOCAN estimates, about 377,713 new cancer patients and 177,757 deaths occurred in 2020 worldwide. The load of oral squamous cell carc [....] » Read More
The discussion will be on optimum utilization of AI and genomics in delivering personalized treatments inRadiationOncology for better treatment outcome. Artificial Intellignce , Machine learing and Deep learning will bediscussedand the future of artificial intelligence in radiati [....] » Read More
Oxidative stress is one of major factors of cancer initiation and progression by inducing damage to cellular macromolecules through the accumulation of reactive oxygen species (ROS). This process contributes to tumor development by triggering events such as DNA mutations, protein [....] » Read More
Background: Immune checkpoint inhibitors (ICIs) improve overall survival (OS) in advanced/metastatic urothelial cancer (a/mUC) patients. Preliminary evidence suggests a prognostic role of inflammatory biomarkers in this setting. We aimed to develop a disease-specific prognostic i [....] » Read More
Undoubtedly, cancer refers to the group called “diseases of civilization”. Over the last 100 years, cancer has become a real nightmare for humanity. Despite having the tremendous world scientific and financial resources, successes in the cancer research and treatment, [....] » Read More
A novel ruthenium(III) complex with 2-aminomethyl benzimidazole (AMBI) has been synthesized and characterized by elemental analysis, spectroscopic (FTIR, UV–Vis and XRD), thermal, magnetic and electrochemical techniques. Characterization shown that the ruthenium ion is oc [....] » Read More
Cancer is a complex pathology of great relevance for public health due to its high mortality and morbidity. Specifically breast cancer, is one of the main causes of death in women worldwide, demonstrating that its incidence has been exponentially uprising. The multifactorial natu [....] » Read More
Introduction: Photodynamic therapy (PDT) promotes wound healing while its clinical use is not investigated in human for radiation-induced skin ulcers. Methods and Materials: We documented the first Canadian in-human case and searched the PubMed literature using “PDT" [....] » Read More
Background: Sarcopenia has been shown to be an independent predictor of lower overall survival in oncology patients. Several studies have used computed tomography (CT) to measure psoas muscle surface area to define sarcopenia. However, the cut-off values based on CT imaging [....] » Read More
Burkitt lymphoma is the most common non-Hodgkin lymphoma in children. Pediatric Burkitt lymphomas (pBLs) are characterized by fast tumor growth; therefore, rapid diagnosis and initiation of therapy is of utmost significance. MicroRNAs (miRNAs) are small non-coding RNAs that were [....] » Read More
Title : Molecular-genetic study of low-grade and high-grade “basal-like” (triple-negative) breast carcinomas
Farid Moinfar, Ordensklinikum Linz Barmherzige Schwestern, Austria
Introduction: Basal-like breast carcinomas are immunohistochemically positive for basal-type keratins such as K 5/6, K14, and K17 and mostly are triple-negative (negativity for ER, PR, and Her2/neu). “Basal-like” or triple-negative breast carcinoma is mostly known as [....] » Read More
Title : Altered expression of endoplasmic reticulum stress response genes and circular RNAs in oral squamous cell carcinoma tumorigenesis
Vandana Tiwari, Dr. Ram Manohar Lohia Institute of Medical Sciences, India
Background: Oral squamous cell carcinoma (OSCC) is a leading malignancy with high mortality and poor prognosis. Dysregulation of endoplasmic reticulum stress response (ERSR) genes and circular RNAs (circRNAs) contributes to its tumorigenesis and progression. Aim: This study ai [....] » Read More
Title : Geospatial variation and assessment of factors with incidence of colorectal cancer at small area
Getachew Dagne, University of South Florida, United States
Background: Examining spatial distribution of colorectal cancer (CRC) incidence or mortality is helpful for developing cancer control and prevention programs, or for generating hypotheses. Such an investigation involves describing the spatial variation of risk factors for colorec [....] » Read More
Title : Flow cytometry for diagnosing malignant carcinomatous effusions
Namrata P Awasthi, Dr. Ram Manohar Lohia Institute of Medical Sciences, India
Background: The lecture will introduce the audience to commonly utilized techniques for Cytology of malignant fluids including cytospin, cell block and immunohistochemistry. The advantages and limitations of the techniques will be discussed. Further, basics of flow cytometry (FCM [....] » Read More
Title : Effectiveness of homoeopathic medicine for brochogenic carcinoma: A case report with pre & post HRCT report
Amir Ashraf, Dr. Amir’s Family Homoeopathy Clinic, India
Homoeopathy is an alternative system of medicine discovered by German physician Samuel Hahnemann in 1796. It has been used by several people for various health conditions globally for more than last 200 years. In India, homoeopathy is considered as a major system of alternative m [....] » Read More
Title : Genome-wide polymorphisms linked to treatment dosing and outcomes in Qatari pediatric acute lymphoblastic leukemia
Zainab Awada, Sidra Medicine, Qatar
Background: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, yet significant inter-individual variability exists in response to its therapy. Genetic polymorphisms as biomarkers for treatment efficacy and toxicity in childhood ALL are limited, part [....] » Read More
Title : The potential of Piper longum extract on breast cancer cell proliferation by inducing apoptosis
Shivam Singh, All India Institute of Medical Sciences, India
Background: The incidence of breast cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. According to anci [....] » Read More
Title : Horizontal comparison of the trend of pancreatic cancer in China and abroad: Lower development correlates with reduced pancreatic cancer burden, defying SDI-based predictions
Yuxin Zhu, Nanchang University, China
Pancreatic cancer (PC), characterized by aggressive progression and poor prognosis, poses a critical global health challenge. This multinational study investigates epidemiological disparities in PC incidence and disease burden through a socio-demographic index (SDI)-stratified an [....] » Read More
Title : Unveiling gaps in cancer care: A qualitative study on the needs of patients from Northeast India
Redolen Rose Dhar, Manipal Academy of Higher Education, India
Background: Cancer is the leading cause of death worldwide, with the WHO projecting a 45% increase in global cancer deaths from 2008 to 2030 (1, 2). Beyond health impacts, cancer imposes significant economic strains, particularly on younger, low-income individuals (3). The extens [....] » Read More
Title : Overcoming resistance in ROS1-positive NSCLC: IDX001 as a promising next-generation therapeutic
Divyapriya Karthikeyan, InDspireX, India
ROS1 (Receptor Tyrosine Kinase ROS Proto-Oncogene 1) mutations in non-small cell lung cancer (NSCLC) lead to the formation of chimeric proteins that activate key oncogenic signaling pathways, contributing to tumorigenesis. These mutations, including ROS1 gene rearrangements such [....] » Read More
Title : Survivin and its splicing isoforms gene expression in oral squamous cell carcinoma patients
Phyu Ou Maung, University of Dental Medicine, Myanmar
Background: Oral squamous cell carcinoma (OSCC) has become a major oncologic problem. Survivin overexpression in OSCC could be associated with increased aggressiveness, poor response to chemotherapy and prediction of patient survival. This study was conducted to analyze the mRNA [....] » Read More
Title : Decoding the universal proliferative engine of pituitary adenomas: From single-cell insights to cross-subtype therapeutic innovation
Changqin Pu, Peking Union Medical College Hospital, China
Objective: Pituitary adenomas (PAs) are clinically heterogeneous tumors with subtype-specific hormonal profiles, yet current therapies remain largely reactive and fail to address their proliferative core. This study challenges the dogma of subtype-driven tumorigenesis by ide [....] » Read More
Title : Temozolomide treatment in refractory pituitary adenomas and pituitary carcinomas
Congcong Deng, Peking Union Medical College Hospital, China
Refractory pituitary adenomas (RPAs) and pituitary carcinomas (PCs) present significant therapeutic challenges, as they often do not respond to conventional treatment modalities such as surgery, radiation, and traditional medical therapies. Temozolomide (TMZ), an alkylating chemo [....] » Read More
Title : Cancer-associated fibroblasts derived soluble CADM1 predicts response to neoadjuvant chemoimmunotherapy in lung cancer
Jian Li, Shanghai Jiaotong University, China
Conventional neoadjuvant chemotherapy offers limited benefit for patients with resectable non-small-cell lung cancer (NSCLC). Recently, neoadjuvant chemoimmunotherapy (NCIT) has transformed perioperative management of NSCLC by priming systemic anti-tumor immunity before surgery, [....] » Read More
Title : Importin7 induces M2 macrophage and promotes the progress of colorectal cancer by regulating the nucleus translocation of GRP78
Changjiang Yang, Peking University People's Hospital, China
Recent research has linked Importin7 to cancer aggressiveness and a dismal prognosis, but its function in colorectal cancer (CRC) is unclear. This study aimed to elucidate the clinical relevance, biological function, and potential molecular mechanisms of IPO7 in CRC. Our results [....] » Read More
Title : Community health workers role in advancing cervical cancer prevention and HPV vaccination in Mukono district, Uganda
Pauline Picho Keronyai, Nama Wellness Community Centre (NAWEC), Uganda
Cervical cancer remains a significant public health challenge in Africa, with the continent bearing approximately 19% of global cases. The East African region reports particularly concerning statistics, with an age-standardized incidence rate of 40.1 per 100,000 women annually, s [....] » Read More
Title : The prevention of post-ESD stricture of large early esophageal cancer by periodic triamcinolone injection
Li Mian Er , The Fourth Hospital of Hebei Medical University, China
Objective:Endoscopic submucosal dissection (ESD) is widely used for early esophageal cancer,but the post-ESD stricture rate of patients with a post-ESD mucosal defect of ≥ 3/4 of the esophageal circumference is extremely high(even reach 90%).Long term repeated endoscopic dilat [....] » Read More
Title : BATF upregulates RGS2 expression to promote T cell exhaustion in lung cancer by activating the NF-kB pathway
Chanchan Gao, Zhongda Hospital, Southeast University, China
Objective: This study aimed to investigate the role of RGS2 in immune regulation and its impact on the efficacy of PD-1/PD-L1 blockade therapy in lung cancer (LC), as well as to explore the regulatory relationship between RGS2 and BATF2 in modulating T cell exhaustion and tumor i [....] » Read More
Title : Advancing cancer care: The impact of MYCNOS-SE on chemoresistance in SCLC
Yuchun Niu, Oncology Hospital of the First People's Hospital of Foshan, China
Understanding the Role of Super-enhancer MYCNOS-SE in Chemoresistance of Small Cell Lung Cancer. Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and a high propensity for chemotherapy resistance. This presentation will discuss [....] » Read More
Title : ADGRE+ CD8+ T cells overcome resistance to neoadjuvant immunotherapy in lung cancer
Jian Li, Shanghai Jiaotong University, China
Neoadjuvant immunotherapy with anti-programmed death-1 (neo-antiPD1) has revolutionized perioperative treatment for improving the overall survival (OS) of patients with early-stage lung cancer. Despite its transformative impact, neo-antiPD1 provides limited benefit to nearly 50% [....] » Read More