Rajvir Dahiya, University of California San Francisco, United States
Background: Current screening methods, have limitations in the diagnosis and prognosis of prostate cancer. This study examined whether mRNA-genomic biomarkers can improve screening and monitoring of prostate cancer. Methods: We identified a panel of 25 prostate cancer-related [....] » Read More
Title : Will be Updated Soon..
Sandrine Lacombe, University of Paris-Saclay, France
Will be Updated Soon...
Title : Molecular-genetic study of low-grade and high-grade “basal-like” (triple-negative) breast carcinomas
Farid Moinfar, Ordensklinikum Linz Barmherzige Schwestern, Austria
Introduction: Basal-like breast carcinomas are immunohistochemically positive for basal-type keratins such as K 5/6, K14, and K17 and mostly are triple-negative (negativity for ER, PR, and Her2/neu). “Basal-like” or triple-negative breast carcinoma is mostly known as [....] » Read More
Title : Principles of oral rehabilitation in H&N cancer patients
Pietro Salvatori, Independent H&N Surgeon, Italy
Treatment goals for Head & Neck cancers can be indicated as: 1) Eradication of the tumor (ablative surgery or XRT, combinations), 2) Restoration of the anatomy (reconstructive surgery), 3) Rehabilitation of the function. Of course, the main goals are to increase survi [....] » Read More
Title : Altered expression of endoplasmic reticulum stress response genes and circular RNAs in oral squamous cell carcinoma tumorigenesis
Vandana Tiwari, Dr. Ram Manohar Lohia Institute of Medical Sciences, India
Background: Oral squamous cell carcinoma (OSCC) is a leading malignancy with high mortality and poor prognosis. Dysregulation of endoplasmic reticulum stress response (ERSR) genes and circular RNAs (circRNAs) contributes to its tumorigenesis and progression. Aim: This study ai [....] » Read More
Title : Geospatial variation and assessment of factors with incidence of colorectal cancer at small area
Getachew Dagne, University of South Florida, United States
Background: Examining spatial distribution of colorectal cancer (CRC) incidence or mortality is helpful for developing cancer control and prevention programs, or for generating hypotheses. Such an investigation involves describing the spatial variation of risk factors for colorec [....] » Read More
Title : Genome-wide polymorphisms linked to treatment dosing and outcomes in Qatari pediatric acute lymphoblastic leukemia
Zainab Awada, Sidra Medicine, Qatar
Background: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, yet significant inter-individual variability exists in response to its therapy. Genetic polymorphisms as biomarkers for treatment efficacy and toxicity in childhood ALL are limited, part [....] » Read More
Title : Cancer-associated fibroblasts derived soluble CADM1 predicts response to neoadjuvant chemoimmunotherapy in lung cancer
Jian Li, Shanghai Jiaotong University, China
Conventional neoadjuvant chemotherapy offers limited benefit for patients with resectable non-small-cell lung cancer (NSCLC). Recently, neoadjuvant chemoimmunotherapy (NCIT) has transformed perioperative management of NSCLC by priming systemic anti-tumor immunity before surgery, [....] » Read More
Title : Importin7 induces M2 macrophage and promotes the progress of colorectal cancer by regulating the nucleus translocation of GRP78
Changjiang Yang, Peking University People's Hospital, China
Recent research has linked Importin7 to cancer aggressiveness and a dismal prognosis, but its function in colorectal cancer (CRC) is unclear. This study aimed to elucidate the clinical relevance, biological function, and potential molecular mechanisms of IPO7 in CRC. Our results [....] » Read More
Title : Chromatin accessibility landscape of pituitary neuroendocrine tumors reveals specific alterations and differentiates Cushing's disease
Shuangjian Yang, Peking Union Medical College Hospital, China
Objective: Cushing's disease (CD) is a debilitating condition caused by corticotropin-secreting pituitary neuroendocrine tumors, resulting in significant morbidity and mortality. Despite its clinical impact, the molecular mechanisms underlying the tumorigenesis of CD hav [....] » Read More
Title : Horizontal comparison of the trend of pancreatic cancer in China and abroad: Lower development correlates with reduced pancreatic cancer burden, defying SDI-based predictions
Yuxin Zhu, Nanchang University, China
Pancreatic cancer (PC), characterized by aggressive progression and poor prognosis, poses a critical global health challenge. This multinational study investigates epidemiological disparities in PC incidence and disease burden through a socio-demographic index (SDI)-stratified an [....] » Read More
Title : Temozolomide treatment in refractory pituitary adenomas and pituitary carcinomas
Congcong Deng, Peking Union Medical College Hospital, China
Refractory pituitary adenomas (RPAs) and pituitary carcinomas (PCs) present significant therapeutic challenges, as they often do not respond to conventional treatment modalities such as surgery, radiation, and traditional medical therapies. Temozolomide (TMZ), an alkylating chemo [....] » Read More
Title : Decoding the universal proliferative engine of pituitary adenomas: From single-cell insights to cross-subtype therapeutic innovation
Changqin Pu, Peking Union Medical College Hospital, China
Objective: Pituitary adenomas (PAs) are clinically heterogeneous tumors with subtype-specific hormonal profiles, yet current therapies remain largely reactive and fail to address their proliferative core. This study challenges the dogma of subtype-driven tumorigenesis by ide [....] » Read More
Title : Elastin nanogel-encapsulated combo drugs for Castration-Resistant Prostate Cancer (CRPC) therapy
Vinoth Kumar Lakshmanan, Sri Ramachandra Institute of Higher Education and Research, India
Prostate cancer (PC) is the most common cancer affecting men and the third leading cause of cancer death. Despite recent advances in detection and localized curative treatment for prostate cancer, 23-40% of those patients will go on to develop metastatic disease. Castration-Resis [....] » Read More
Title : Flow cytometry for diagnosing malignant carcinomatous effusions
Namrata P Awasthi, Dr. Ram Manohar Lohia Institute of Medical Sciences, India
Background: The lecture will introduce the audience to commonly utilized techniques for Cytology of malignant fluids including cytospin, cell block and immunohistochemistry. The advantages and limitations of the techniques will be discussed. Further, basics of flow cytometry (FCM [....] » Read More
Title : Unveiling gaps in cancer care: A qualitative study on the needs of patients from Northeast India
Redolen Rose Dhar, Manipal Academy of Higher Education, India
Background: Cancer is the leading cause of death worldwide, with the WHO projecting a 45% increase in global cancer deaths from 2008 to 2030 (1, 2). Beyond health impacts, cancer imposes significant economic strains, particularly on younger, low-income individuals (3). The extens [....] » Read More
Title : The potential of Piper longum extract on breast cancer cell proliferation by inducing apoptosis
Shivam Singh, All India Institute of Medical Sciences, India
Background: The incidence of breast cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. According to anci [....] » Read More
Title : Synthesis and characterization of ruthenium(III) complex containing 2-aminomethyl benzimidazole, and its anticancer activity in in vitro and in vivo models
Abdel Ghany F. Shoair, Damietta University, Egypt
A novel ruthenium(III) complex with 2-aminomethyl benzimidazole (AMBI) has been synthesized and characterized by elemental analysis, spectroscopic (FTIR, UV–Vis and XRD), thermal, magnetic and electrochemical techniques. Characterization shown that the ruthenium ion is oc [....] » Read More
Title : The interplay between viruses and cancer: Mechanisms and therapeutic implications
Aida Abbasi, Tehran University of Medical Sciences, Iran (Islamic Republic of)
The relationship between viruses and cancer has garnered significant attention in recent decades, revealing a complex interplay that contributes to tumorigenesis. Certain viruses, known as oncoviruses, have been identified as key players in the initiation and progression of vario [....] » Read More
Title : Survivin and its splicing isoforms gene expression in oral squamous cell carcinoma patients
Phyu Ou Maung, University of Dental Medicine, Myanmar
Background: Oral squamous cell carcinoma (OSCC) has become a major oncologic problem. Survivin overexpression in OSCC could be associated with increased aggressiveness, poor response to chemotherapy and prediction of patient survival. This study was conducted to analyze the mRNA [....] » Read More
Title : Community health workers role in advancing cervical cancer prevention and HPV vaccination in Mukono district, Uganda
Pauline Picho Keronyai, Nama Wellness Community Centre (NAWEC), Uganda
Cervical cancer remains a significant public health challenge in Africa, with the continent bearing approximately 19% of global cases. The East African region reports particularly concerning statistics, with an age-standardized incidence rate of 40.1 per 100,000 women annually, s [....] » Read More
Title : Chalepin suppresses cell growth by down-regulation of the epidermal growth factor receptor downstream pathways and induced cell cycle arrest in MCF7 breast cancer cells
Isah Musa Fakai, Kebbi State University of Science and Technology, Nigeria
The epidermal growth factor receptor (EGFR) pathway is an important signaling cascade currently investigated for its involvement in cancer therapy. In this study, chalepin isolated from Ruta angustifolia was evaluated for its down regulatory activity on the EGFR signaling cascade [....] » Read More
Title : Machine learning models based on preoperative contrast-enhanced CT radiomics for differential diagnosis of xanthogranulomatous cholecystitis and thick-walled gallbladder carcinoma
Qi Li, The First Affiliated Hospital of Xi'an Jiaotong University, China
Will be Updated Soon...
Title : Refined ypTNM staging for gastric cancer after neoadjuvant therapy based on optimal lymph node staging
Baolong Li, Fujian Medical University Union Hospital, China
Background: The 8th edition of the AJCC staging system for gastric cancer introduced the ypTNM staging. However, in clinical practice, we have observed that the accuracy of its prognostic assessment remains controversial. This study aims to develop a more precise and refined ypTN [....] » Read More
Title : Supramolecularly engineered bacteria-mediated innovative drug delivery for immunotherapy of tumors
Beibei Xie, University of Macau, China
Although various ferroptosis inducers including magnetic nanoparticles (Fe3O4) and iron-organic frameworks have been applied in cancer treatment, the mild immunogenicity, low targeting efficiency to the tumor, and poor tissue penetration have limited the therapeutic efficacy. Her [....] » Read More
Title : CANEZA: Investigating the potential of ginger, lemon, and soursop leaves in cancer treatment
Najjemba Eseza Precious, Mengo Senior School, Uganda
Introduction: Cancer remains one of the leading causes of mortality worldwide, with conventional treatments such as chemotherapy, radiation, and surgery often causing severe side effects. Natural medicine has gained attention as a potential complementary approach to cancer care. [....] » Read More
Title : Understanding the role of super enhancer MYCNOS-SE in chemoresistance of small cell lung cancer
Niu Yuchun, Oncology Hospital of the First People's Hospital of Foshan, China
Understanding the Role of Super-enhancer MYCNOS-SE in Chemoresistance of Small Cell Lung Cancer. Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and a high propensity for chemotherapy resistance. This presentation will discuss [....] » Read More
Title : BATF upregulates RGS2 expression to promote T cell exhaustion in lung cancer by activating the NF-kB pathway
Chanchan Gao, Zhongda Hospital, Southeast University, China
Objective: This study aimed to investigate the role of RGS2 in immune regulation and its impact on the efficacy of PD-1/PD-L1 blockade therapy in lung cancer (LC), as well as to explore the regulatory relationship between RGS2 and BATF2 in modulating T cell exhaustion and tumor i [....] » Read More
Title : A novel treatment for advanced bladder cancer using microwave/radiofrequency ablation: Two successful cases
Yu Yang, Beijing Friendship Hospital, Capital Medical University, China
Introduction: Bladder cancer is one of the top 10 most common cancers. Although radical cystectomy (RC) is the standard treatment, it significantly compromises quality of life. This study explores percutaneous ablation as a main treatment combined with multimodal therapy as [....] » Read More
Title : ADGRE+ CD8+ T cells overcome resistance to neoadjuvant immunotherapy in lung cancer
Jian Li, Shanghai Jiaotong University, China
Neoadjuvant immunotherapy with anti-programmed death-1 (neo-antiPD1) has revolutionized perioperative treatment for improving the overall survival (OS) of patients with early-stage lung cancer. Despite its transformative impact, neo-antiPD1 provides limited benefit to nearly 50% [....] » Read More
Title : The impact of social marketing based intervention on educating esophageal cancer preventive behaviors
Davoud Shojaeizadeh, Tehran University of Medical Sciences, Iran (Islamic Republic of)
Esophageal cancer is one of the most widespread disease in Golestan Province , Iran. To identify risk factors a lot of research has been done. Because health workers have successful experiences of health education. The purpose of this study is to use social marketing to influence [....] » Read More
Title : Euxanthone suppresses the proliferation of human hepatocellular carcinoma cells via miR-199a-5p/E2F3 axis
Ahmed Al Awadh, Najran University, Saudi Arabia
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. This study aimed to evaluate the effects of euxanthone on the proliferation and migration of HCC cell lines and elucidate the underlying molecular mechanisms. Methods: HCC cell [....] » Read More
Title : In-vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions
Liu, Shanghai Pulmonary Hospital, China
Introduction: CRISPR functional genomic screens have been widely adopted to identify essential genes and potential drug targets in cell line models. However, it is well known that cell line models studied in vitro do not fully capture the biology in patient tumors due to the lack [....] » Read More
Title : Overcoming resistance in ROS1-positive NSCLC: IDX001 as a promising next-generation therapeutic
Divyapriya Karthikeyan, InDspireX, India
ROS1 (Receptor Tyrosine Kinase ROS Proto-Oncogene 1) mutations in non-small cell lung cancer (NSCLC) lead to the formation of chimeric proteins that activate key oncogenic signaling pathways, contributing to tumorigenesis. These mutations, including ROS1 gene rearrangements such [....] » Read More
Title : Study of the participatory communication on good territorial governance performance in Tantan city, Morocco
Hefdhallah Al-Aizari, Ibn Tofail University, Morocco
Participatory and collaborative communication plays a crucial role in territorial governance to find innovative solutions for the proper functioning of public service. This study examines the importance of participatory and collaborative communication in good territorial governan [....] » Read More