Title : Evaluation of mutational values in cancerous point mutation and innovation of values-effective drugs for cancer treatment
Abstract:
The molecular weights of amino acids are time values where integer and decimal part have separate identity but interrelated. Derived from the factor 14.0267 e.g. 119.1197(Thr) – 105.0930(Ser) = 14.0267 = 131.1736(Leu) – 117.1469(Val), the formula T(time) = 0.0019*M(integer) is important with a difference of 0.0001 or 1 associated with directional biology. The values 0.0267 = 0.0154 + 0.0113(6) are factors of opposite since 0.1605 – 0.1451 = 0.0154 and 777(183) – 771(i.e. 357 + 414) = 6 and conversely 177 + 6 = 183(lunar time). To evaluate mutational values, the core values(Cv) of amino acid have to be measured e.g. 181.1894(Tyr) = 181*0.0019 – 0.1894 = 0.1545 or 645(under suppression) = 900 – 255. The biophysical structure or electro-gravitational structure works within 900 and the reverse domain 109 and Tyr-Val chemistry constitutes an electro-gravitational structure where 289 + 136 = 425 = 938 – 513(27) and also Tyr-Met chemistry constitutes an electro-gravitational structure where 519 + 289 = 808 and conversely 519 – 289 = 230 where 808 – 230 = 578 = 575 + 3. The values are measured from lunar gravity(0.1605 or 705) with decimal part where 0.2124(Met) – 0.1605 = 0.0519 or 519, 0.1894(Tyr) – 0.1605 = 0.0289 or 289 and 0.1605 – 0.1469(Val) = 0.0136 or136. The electro-gravitational structure is based on 0.3477(183) – 0.2902(i.e.0.1451*2) = 0.0575 or 575 = 0.1605 – 0.1031(i.e. 900 – 131= 769 that reverse of 967 where 193*0.0019 = 0.3667 or 967) where 0.1451 = 0.0938 + 0.0513. The molar masses of proton 938.28 Mev/C2 and that of electron 0.511Mev/C2 with a significant 0.0002 time difference. The electro-gravitational structure activates if there is a difference of 100 towards structural mutation or blocking of time by ‘9’(0.0171 or 171) where 289 shows tyrosine kinase activity due to blocking of time in directional biology and 28*82 = 2296 or 496 where 575 + 496 = 1071 or 171 and conversely 496 – 325 = 171 in 900 = 575 + 325 and if 575 is positive then 325 runs negative. There are some crucial structure, 900 = 360 + 540 = 289 + 611 = 645 + 255 = 513 + 387 in the system where the intermediate values 645 – 255 = 390 is associated with 109 where 390 + 109 = 499(reverse of 994) and 289 – 255 = 34(i.e. 0.0646) is significant. The JAK2 G1849T V617F and TP53 G469T V157F would be standard manifestation where core values of Val = 754 = 900 -146(complementary values of 469 point) and 705 + 49(beyond 900) = 754 and 109 + 49 = 158. The Val754 can be a pathfinder for drug assessment. The EGFR lung cancer mutations L858R, C797S and T790M are interrelated where 858 + 797 = 1655 or 755 and 858 – 109 = 749 and 797 – 109*2 = 579 are the causes of cancer since time is indomitable and cannot be stopped. It is found 790 – 540 = 250 = 575 – 325 where 360 – 250 = 110(suppressed). In BRAF V600E, 754 – 600 = 154 and 600 – 6 = 594(E) where 154 + 6 = 160 causes cancer.
