Background Drug resistance, including Adriamycin-based therapeutic resistance, remains a challenge in breast cancer (BC) treatment. Studies have revealed that macrophages could play a pivotal role in mediating the chemoresistance of cancer cells. Accumulating evidence suggests th [....] » Read More
Objective: The purpose of this study is to investigate and analyze the nutritional risk anditsdynamic changing trend of breast cancer patients in the process of disease treatment. Methods: The nutritional risk screening data of breast cancer patients treated in our h [....] » Read More
Matrix metalloproteinases (MMPs), notably the soluble gelatinases MMP-2 and MMP-9, are central to extracellular matrix remodeling and are frequently dysregulated during tumor invasion and metastatic progression, making them attractive biomarkers for early detection and prognosis [....] » Read More
Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, has emerged as a critical driver of malignancy in diverse cancers such as anaplastic large cell lymphoma, non-small cell lung cancer, and neuroblastoma. Although ALK is normally activated by its ligands ALKAL1 and ALKA [....] » Read More
Ovarian Cancer (OC) is the 3rd most common gynecological cancer worldwide with high morbidity and mortality rate and Epithelial Ovarian Cancer (EOC) is the most common subtype (90%). Despite advances in treatment, late diagnosis and inadequate therapeutic options continue to be t [....] » Read More
The experiment aimed to investigate the protective effects of Silymarin (SMN) against methotrexate (MTX) induced nephropathy in rabbits. In a randomized control trial, a total of 20 rabbits were allocated into 4 different groups each containing 5 rabbits. The first group (Control [....] » Read More
Background: Iodine-125 balloon brachytherapy is an innovative technique for delivering localized low-dose-rate radiation after the surgical removal of malignant brain tumors. The spherical shape of post-resection cavities makes the balloon applicator an effective choice for achie [....] » Read More
Colon cancer remains a major global health challenge, and the severe side effects of conventional chemotherapy necessitate the development of novel therapeutic strategies. This study aimed to synthesize and evaluate a hesperetin-loaded graphene oxide nanocomposite (Hsp-GO) as an [....] » Read More
Early detection of multiple cancer types (MCED) is essential for improving patient outcomes, particularly for cancers lacking routine screening methods. Existing diagnostic approaches are often invasive, focused on single cancer types, and limited in sensitivity—especially [....] » Read More
Background: In Malawi, lung cancer is under-diagnosed and under-reported due to overlapping symptoms with tuberculosis, limited diagnostic capacity and fragmented data systems. Existing cancer registry tools inadequately capture lung cancer- specific indicators, and frontline hea [....] » Read More
Title: Solid Pseudopapillary Neoplasms of the Pancreas: A Decade-Single Institution Experience in Diagnosis, Surgical Management and Long-Term Outcomes. Background & Objectives: Solid pseudopapillary neoplasm (SPN) is an uncommon pancreatic epithelial neoplasm that prefere [....] » Read More
Esophageal cancer is one of the most widespread disease in Golestan Province , Iran. To identify risk factors a lot of research has been done. Because health workers have successful experiences of health education. The purpose of this study is to use social marketing to influence [....] » Read More
Background: Chemotherapy-induced cardiotoxicity is a major complication in patients with acute leukemia, often associated with oxidative stress. The glutathione peroxidase 4 (GPX4) gene play a critical role in antioxidant defense and cellular protection. This study evaluated the [....] » Read More
Introduction: Systemic cancer therapies, including chemotherapy and immunotherapy, often contribute to substantial symptom burden and psychosocial distress, negatively affecting patients’ quality of life (QoL). Complementary and integrative therapies—particularly musi [....] » Read More
Background: Navigational bronchoscopy (NB) techniques, such as electromagnetic navigation bronchoscopy (ENB), virtual bronchoscopic navigation (VBN), and others, have been developed to improve lesion localization and sampling of peripheral pulmonary nodules (PPN). However, their [....] » Read More
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive behavior and a high propensity for metastasis, typically to the liver, peritoneum, and lungs. Metastatic involvement of the colon, however, is exceptionally uncommon a [....] » Read More
Background: The National Institute of Health (NIH )in the USA has published a scientific research on cancer treatment by a pathogenic bacteria like Salmonella after genetically modified. The idea of treating tumors with bacteria is an old idea, but from the premise of public safe [....] » Read More
Current screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limited. To [....] » Read More
Biosensor technology represents an attractive strategy for the detection and monitoring of biomarkers for disease states within the context of precision medicine. In the present paper we discuss the application of biosensor technology for the early-stage detection of ovaria [....] » Read More
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In this keynote talk, the use of the Hill model to assess the Benchmark dose (BMD), the lethal dose 50 (LD50), the cooperativity (E), and the dissociation constant (K) while analyzing cell viability data using nanomaterials will be explored. The presentation is addressed to discu [....] » Read More
Chromatin bridges are strings of mis-segregated chromatin connecting the anaphase poles or daughter nuclei in mitotic cell division and can arise from incomplete DNA replication or decatenation, or from dicentric chromosomes generated by end-to-end chromosome fusions. Chromatin b [....] » Read More
Gastric adenocarcinoma (GAC) remains one of the leading causes of cancer-related mortality worldwide, largely due to its late-stage diagnosis, limited treatment options, and poorly understood molecular drivers. Recent studies have implicated epigenetic dysregulation in GAC pathog [....] » Read More
Introduction: Cancer in adolescents and young adults (AYAs) is a worldwide devastating disease. In the US, it is among the top four causes of AYA deaths. Cancer signs/symptoms are similar to common ailments, delaying diagnosis, thus life-threatening. Less than o [....] » Read More
Aim: Degarelix, a GnRH antagonist for ADT, showed remarkable results in clinical trials. We launched Canada’s first off-site injection program to decentralize services from overloaded acute care settings. This is the first reported Canadian community experience with degarel [....] » Read More
Postmenopausal breast cancer (PBC) constitutes a major proportion of global breast cancer incidence, with excess adiposity recognised as a significant modifiable risk factor. Following menopause, visceral adipose tissue becomes the primary source of oestrogen through increased ar [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More
Breast cancer remains the most prevalent malignancy among women in the Gaza Strip, where patients face not only the physical burden of the disease but also the compounded effects of ongoing crisis conditions. This study explores nursing strategies and challenges in managing chemo [....] » Read More
Aims: An unhealthy lifestyle elevates the risk of comorbidities, cancer recurrence, and diminished quality of life among breast cancer survivors. Yet, the influence of psychosocial factors on sustaining healthy lifestyle behaviors (physical activity and healthy diet) in this po [....] » Read More
Multiple myeloma (MM) is one of the most frequent hematological malignancies. Its incidence and mortality rate is globally increasing. Most MM patients experience relapse, which leads to poor prognosis. The genes associated with MM development or relapse have not been totally elu [....] » Read More
Introduction: Cancer is one of the leading causes of mortality; breast cancer is the most frequent type worldwide and in Mexico. Therefore, treatment options such as heterosteroids continue to be investigated. To establish their effect on breast cancer, in silico simulation must [....] » Read More
Osteoporosis, characterized by an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, severely affects elderly health. Currently, there are no effective treatments, highlighting the need for new therapies. Salvia miltiorrhiza Bunge, a tra [....] » Read More
The proliferative biophysical structure is associated with Earth’s or Lunar time(183 or 777), Earth’s gravity(734) and Lunar gravity(0.1605 or 705) in context of 900-109(reverse) fundamental mathematical complex with a directional difference of 1 that would be respons [....] » Read More
Introduction and Objective: Radiation therapy is a cornerstone of cancer treatment, yet its efficacy is often limited by inherent or acquired tumour radio resistance and the potential for long-term adverse effects. Understanding the genomic alterations induced by radiation and th [....] » Read More
Glioblastoma Multiforme (GBM) is a stage IV brain tumour is complex and deadly diseases. There is no promising therapeutic applications for GBM, and so many drugs are developed, and screened in pre- clinical/clinical tests. To understand the mechanism of GBM cancer causes the cel [....] » Read More
Objective: I aimed to investigate the potential immunomodulatory role of complex Autophagy, Toll-like Receptors and PI3-Akt signaling networks/cross-talks in single cell immunobiology by targeting circulating tumor cells in benign prostate hyperplasia and prostate cancer for even [....] » Read More
New molecular diagnostic tools, such as circulating tumor DNA (ctDNA), and an emphasis on pinpoint accuracy are changing radiation oncology. By integrating stereotactic body radiation therapy (SBRT) with ctDNA tracking from liquid biopsies, this study investigates a new way to tr [....] » Read More
Cardiotoxicity makes it harder to maximize cancer survival rates; radiation and chemotherapy do more than just harm cells directly; they also worsen irreversible heart damage. By addressing a significant knowledge vacuum about the precise role of the gut microbiome in cardiotoxic [....] » Read More
Introduction: Spermatogonial stem cell transplantation (SSCT) offers a promising strategy to restore fertility in childhood cancer survivors. Chemotherapy agents like busulfan and cadmium cause oxidative damage, which impairs spermatogenesis. Metformin, known for its antioxi [....] » Read More
Nelson Mandela Academic Hospital (NMAH) is a tertiary teaching hospital in Mthatha that has recently expanded oncology services to better serve patients across the Eastern Cape. Regional analyses highlight limited oncology capacity, a high burden of advanced-stage cancers, and re [....] » Read More
Background : Breast cancer parotid gland metastasis is extremly rare, accounting for less than 0.3% of secondary parotid tumors. Optimal management remains unclear due to limited evidence. We report an unusual case of parotid metastasis occurig in a partient with HR positive HER2 [....] » Read More
Objective: This study aimed to identify the risk factors associated with postoperative complications in elderly patients (≥65 years) undergoing pancreaticoduodenectomy, determine the key moderating factor influencing the choice of surgical approach (open vs. minimally invasive [....] » Read More
Background: Prostate adenocarcinoma (PRAD) is one of the most common malignancies of the male genitourinary system, yet its molecular pathogenesis remains unclear. Recent evidence suggests that FMO5 may play an important role in tumor development; however, its involvement in [....] » Read More
Title : Nanomedicine in humans: 30 years of fighting diseases
Thomas J Webster, Northeastern University, United States
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Title : Personalized and Precision Medicine (PPM) through the view of biodesign-inspired translational research: An option for clinical oncologists, caregivers, and consumers to realize the potential of genomics-informed care to secure human biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will pe [....] » Read More
Title : Underrepresentation of rural communities in cancer-related clinical trials
Allen Chen, Olympic Medical Center, United States
Despite consistent improvements in cancer prevention and care, rural and urban disparities in cancer incidence persist in the United States and in the world. Cancer incidence rates are generally higher in rural populations compared to urban ones, particularly for those [....] » Read More
Title : Personalized and precision oncology via integrating genomics, pathology-related modeling, and IT-assisted approaches to prevent, treat, and cure cancer and its complications
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Individualizing patient treatment is a core objective of the medical field. Meanwhile, the inherent variability of cancer illustrating the molecular differences between tumors, securing the linkages of those differences to an effective drug and resulting in immense patient benefi [....] » Read More
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
In this study we are the first worldwide to reveal a GP73-mediated regulatory network that promotes tumor angiogenesis and progression in Hepatocellular carcinoma (HCC) under hyperxia stress. Our findings demonstrated that GP73 plays crucial roles in tumor angiogenesis nich [....] » Read More
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China
Chemoresistance remains the predominant cause of treatment failure in osteosarcoma (OS), yet its underlying molecular circuitry remains poorly defined. To address this gap, we conducted a series of mechanistic and clinically informed studies integrating molecular biology, epitran [....] » Read More
Title : Spatial multi-omics inference of diabetes-triggered pancreatic cancer growth: The key role of cholesterol-induced neutrophil extracellular
Guanqun Li, The First Affiliated Hospital of Harbin Medical University, China
Objective: Pancreatic ductal adenocarcinoma (PDAC) patients with diabetes mellitus (DM) are associated with poor clinical outcome, while the mechanism remains unclear. Metabolic reprogramming of cancer cells and immune compartments determines the anti-tumor immune response in PDA [....] » Read More
Title : A prospective study of tislelizumab combined with radiotherapy in unresectable or recurrent advanced hepatocellular carcinoma: Efficacy and immunological safety analysis
Han Sun, Liaoning Cancer Hospital & Institute, China
Background: Radiotherapy (RT) can induce immunogenic cell death and enhance tumor antigen release and presentation, thereby augmenting the host anti-tumor immune response. The combination of PD-1 inhibitor tislelizumab with RT may produce synergistic effects and improve outcomes [....] » Read More
Title : Evaluation of survival prognostic factors in different treatment modalities for locally advanced unresectable esophageal squamous cell carcinoma
Yanni Zhang, Liaoning Cancer Hospital & Institute, China
Background: Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), remains a leading cause of cancer-related mortality worldwide. This study investigates the impact of different treatment modalities, namely concurrent chemoradiotherapy (CCRT), chemoimmunothera [....] » Read More
Title : A case-based approach using IMPeTUs criteria in FDG PET/CT reporting of multiple myeloma
Mudalsha Ravina, All India Institute of Medical Sciences, India
[18F]FDG PET/CT has become an integral component in the evaluation of Multiple Myeloma (MM), offering significant advantages in disease detection, staging, treatment response assessment, and prognostication. The Italian Myeloma criteria for PET Use (IMPeTUs) provide a standardize [....] » Read More
Title : Bio-inspired optimization and AI interpretability for melanoma classification
Sabura Banu Urundai Meeran, Saveetha Engineering College, India
The early and precise diagnosis of melanoma plays a crucial role in improving survival rates and enabling timely intervention. However, automated melanoma detection systems face challenges due to image artifacts, illumination variation, and inter-class similarities. This study in [....] » Read More
Title : Unmasking the cytokine storm: A spectrum of paediatric hemophagocytic lymphohistiocytosis across immuno-oncologic, infectious, and genetic landscapes - insights from a tertiary oncology centre in South India
Megadeepan Senthil Kumar, Kidwai Memorial Institute of Oncology, India
Background: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with heterogeneous triggers, ranging from genetic predispositions and immunodeficiencies to malignancies and infections. We report four paediatric cases highlighting the clinical spectrum, diagno [....] » Read More
Title : An overview of homoeopathic treatment as a peerless management in the palliative care of a case of stomach adenocarcinoma
Amir Ashraf, Dr. Amir’s Family Homoeopathy Clinic, India
Adenocarcinoma of the stomach begins in the mucus producing cells in the innermost lining of the stomach. Nearly all stomach cancers are adenocarcinoma. Adenocarcinoma of the stomach is divided into two main classes, depending on where it forms in the stomach.Gastric cardia ca [....] » Read More
Title : Transforming cancer care: Innovations, integrations, and impact
Shayan Maqsood, Jamia Hamdard University, India
Cancer is a complex heterogenous disease that is constantly evolving; and remains a persistent anomaly. The intricacy of cancer treatment presents a complicated woven biological spectrum encompassing various dimensions including genetics, epigenetics and the tumour microenvironme [....] » Read More
Title : Advanced nanoparticles, the hallmark of targeted drug delivery for osteosarcoma
Shayan Maqsood, Jamia Hamdard University, India
Osteosarcoma (OS) is a malignant bone cancer often linked to bone degradation caused by excessive osteoclast activity. Recent advancements in nanotechnology have greatly advanced the development of tumor-specific drug delivery nanocarriers (NCs), including smart and functionalize [....] » Read More
Title : Lifestyle, reproductive factors, and gene expression patterns in breast cancer among rural Indian women
Neetu Kalra, Azim Premji University, India
Breast cancer is one of the most common cancers among women, accounting for over 23% of all cancer-related fatalities in India. This study aimed to identify the risk factors associated with breast cancer among women living in rural regions of Madhya Pradesh. A hospital-based retr [....] » Read More
Title : Revolutionizing psychological care in oncology: A comprehensive review of emerging technologies and their impact on cancer patients
Manijeh Firoozi, University of Tehran, Iran (Islamic Republic of)
Background: The psychological impact of cancer is profound, influencing the quality of life, treatment adherence, and overall outcomes for patients. With advancements in technology, new therapeutic modalities have emerged, offering innovative ways to address the psychological nee [....] » Read More
Title : A systematic review of medical art therapy for cancer patients
Manijeh Firoozi, University of Tehran, Iran (Islamic Republic of)
Background: Art therapy has gained recognition as a valuable complementary treatment for cancer patients, helping to alleviate emotional and psychological stress. This systematic review aims to explore the efficacy of various types of medical art therapy and identify characterist [....] » Read More
Title : Decentralising and decolonising urology palliative care psychosocial services: A model for Nelson Mandela Academic Hospital, urology clinic, Eastern Cape
Awam Mavimbela, Nelson Mandela Academic Hospital, South Africa
Background: Patients with advanced urological conditions in the Eastern Cape face multiple barriers to quality palliative psychosocial care: centralised specialist services, limited integration of culturally relevant practices, transport and cost burdens, and mistrust rooted in h [....] » Read More
Title : Beauty of herbal medicine in the global fight for cancer
Najjemba Eseza Precious, Mengo Senior School, Uganda
Introduction: Cancer remains one of the leading causes of mortality worldwide, with conventional treatments such as chemotherapy, radiation, and surgery often causing severe side effects. Natural medicine has gained attention as a potential complementary approach to cancer care. [....] » Read More
Title : Stakeholder engagement process for multinational lung cancer control programme for Malawi
Tumaini Malenga, Facilitators of Community Transformation (FACT Malawi), Malawi
Introduction: Lung cancer remains a critical public health concern globally. With a variation of risk factors, it remains the leading cause of cancer-related death and has a considerably high burden in sub-Saharan Africa . There is a deficiency in data for Malawi for several reas [....] » Read More
Title : Self-employed cancer survivors
Miri Cohen, University of Haifa, Israel
Objective: Although awareness of the effect of cancer on self-employed individuals is growing, few studies have explored processes of coping in relation to the changes in cancer survivors’ business operations. We examined: (a) identify the perceived effects of cancer on bus [....] » Read More
Title : Application of a machine learning-based tumor risk prediction system to assist in precise diagnosis of prostate cancer and biopsy decision-making
Zhou Yu, Shenzhen People's Hospital, China
Objective: To develop a prediction model for prostate biopsy based on machine learning algorithms and create a tumor risk prediction system, aiming to achieve precise diagnosis of prostate cancer and assist in biopsy decision-making. Methods: Clinical data were retrospectively [....] » Read More
Title : Role of financial toxicity, psychological distress, and perceived social support on satisfaction of life among patients diagnosed with cancer in Pakistan
Muhammad Hammad, Shifa Tameer-e-Millat University, Pakistan
Purpose: To investigates the impact of financial toxicity and psychological distress on life satisfaction among cancer patients, with a specific focus on the mediating role of perceived social support. Materials and Methods: This cross-sectional study was conducted at Pakistan [....] » Read More