Chromatin bridges are strings of mis-segregated chromatin connecting the anaphase poles or daughter nuclei in mitotic cell division and can arise from incomplete DNA replication or decatenation, or from dicentric chromosomes generated by end-to-end chromosome fusions. Chromatin b [....] » Read More
A special effort is needed to improve patient information and patient conversation in radiation oncology. This focus does not only improve patient satisfaction but also contributes to overall quality care and outcome of radiation oncology therapies. With tight resources high qual [....] » Read More
In this keynote talk, the use of the Hill model to assess the Benchmark dose (BMD), the lethal dose 50 (LD50), the cooperativity (E), and the dissociation constant (K) while analyzing cell viability data using nanomaterials will be explored. The presentation is addressed to discu [....] » Read More
Biosensor technology represents an attractive strategy for the detection and monitoring of biomarkers for disease states within the context of precision medicine. In the present paper we discuss the application of biosensor technology for the early-stage detection of ovarian canc [....] » Read More
This presentation will cover a close to 30 year journey researching and commercializing nanotechnology for improving disease prevention, diagnosis, and treatment (including cancer) which has led to numerous products including nano spinal implants now in over 30,000 patients to da [....] » Read More
Current screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limited. To [....] » Read More
Aims: An unhealthy lifestyle elevates the risk of comorbidities, cancer recurrence, and diminished quality of life among breast cancer survivors. Yet, the influence of psychosocial factors on sustaining healthy lifestyle behaviors (physical activity and healthy diet) in this po [....] » Read More
The aim of the study was to examine the possibility of using the urinary concentration of 1-hydroxypyrene for screening high-risk male individuals for bladder cancer. Radosavljević′s urinary screening protocol for the key chemical carcinogens used. Numerical data were arit [....] » Read More
Objective: I aimed to investigate the potential immunomodulatory role of complex Autophagy, Toll-like Receptors and PI3-Akt signaling networks/cross-talks in single cell immunobiology by targeting circulating tumor cells in benign prostate hyperplasia and prostate cancer for even [....] » Read More
The proliferative biophysical structure is associated with Earth’s or Lunar time(183 or 777), Earth’s gravity(734) and Lunar gravity(0.1605 or 705) in context of 900-109(reverse) fundamental mathematical complex with a directional difference of 1 that would be respons [....] » Read More
Cancer has emerged as a major global public health challenge, affecting populations across all age groups. Once considered a rare and inexplicable disease, advances in biomedical sciences have established that cancer arises from identifiable biological, environmental, nutritional [....] » Read More
Multiple myeloma (MM) is one of the most frequent hematological malignancies. Its incidence and mortality rate is globally increasing. Most MM patients experience relapse, which leads to poor prognosis. The genes associated with MM development or relapse have not been totally elu [....] » Read More
Glioblastoma Multiforme (GBM) is a stage IV brain tumour is complex and deadly diseases. There is no promising therapeutic applications for GBM, and so many drugs are developed, and screened in pre- clinical/clinical tests. To understand the mechanism of GBM cancer causes the cel [....] » Read More
Introduction and Objective: Radiation therapy is a cornerstone of cancer treatment, yet its efficacy is often limited by inherent or acquired tumour radio resistance and the potential for long-term adverse effects. Understanding the genomic alterations induced by radiation and th [....] » Read More
The landscape of pediatric oncology in India is undergoing a documented epidemiological transformation, with data-driven projections from the National Cancer Registry Programme (NCRP) forecasting a 12.8% escalation in new diagnoses by late 2026. This investigation identifies a cr [....] » Read More
Introduction: Cancer in adolescents and young adults (AYAs) is a worldwide devastating disease. In the US, it is among the top four causes of AYA deaths. Cancer signs/symptoms are similar to common ailments, delaying diagnosis, thus life-threatening. Less than o [....] » Read More
Introduction: Artificial Intelligence (AI) is a burgeoning tool in the field of surgery. AI technology is vastly unexplored with few applications currently in use. High risk incidental findings in radiologic studies are recognized as a critical source of missed or delayed cancer [....] » Read More
As in some other sites of the head and neck, a broad range of tumours can arise in the nasopharynx: epithelial, mesenchymal, lymphoid, and neuro-ectodermal. However, naso-pharyngeal carcinoma (NPC) is the most interesting and intriguing type, because it is a “peculiar&rdquo [....] » Read More
The challenge of radiotherapy is to increase radiation damage on tumor whilst preserving healthy tissue. Particle therapy offers an alternative method whose ballistic properties improve tumor targeting. However the development of this radiation molality is limited by the impact o [....] » Read More
Noncoding RNAs (ncRNAs) transcribed from noncoding regions of the human genome are highly active and functionally significant; however, the nature of their functional system remains a subject of debate. Recent advances in big data and artificial intelligence have enabled a concep [....] » Read More
MicroRNAs are small non-coding RNA molecules that play a significant role in many physiological processes in the body, including posttranscriptional regulation of gene expression. Their expression in cancer cells can become dysregulated to influence the devlopment of cancer. Alth [....] » Read More
Chromatin bridges are DNA strings that link anaphase poles or daughter nuclei and are associated with carcinogenesis. DNA bridges occur from the separation of twisted, linked chromatin that is caused by problems in DNA replication or incomplete DNA decatenation. In response to [....] » Read More
The Head and Neck Oncology Division (HNOD) of the National Cancer Institute of Milan (NCI), once equipped with 66 beds, operating rooms, and daily outpatient clinics, has been a leading center for elective and salvage surgery for head and neck tumors since the 1960s. Approximatel [....] » Read More
The therapeutic outcomes of medications were restricted by the colonic mucosal barrier during the treatment of colorectal cancer (CRC). Micro/nanomotors can overcome the mucus barriers to reach deep colorectal tumors. In this study, we constructed a novel microsized PLGA-Pt micro [....] » Read More
Objective: To evaluate the efficacy and safety of high-intensity focused ultrasound ablation in the treatment of pancreatic cancer and to analyze relevant prognostic factors. Methods: A retrospective analysis was conducted on 68 patients with pancreatic cancer who underwent [....] » Read More
Breast cancer is one of the most common cancers among women, accounting for over 23% of all cancer-related fatalities in India. This study aimed to identify the risk factors associated with breast cancer among women living in rural regions of Madhya Pradesh. A hospital-based retr [....] » Read More
Ovarian Cancer (OC) is the 3rd most common gynecological cancer worldwide with high morbidity and mortality rate and Epithelial Ovarian Cancer (EOC) is the most common subtype (90%). Despite advances in treatment, late diagnosis and inadequate therapeutic options continue to be t [....] » Read More
Melanoma progression is critically shaped by the tumor microenvironment, where tumor- associated macrophages predominantly acquire an immunosuppressive M2-like phenotype. Osteopontin (OPN), a secreted glycoprotein overexpressed in melanoma, has been implicated in immune modulat [....] » Read More
This scoping review systematically maps the evidence on nursing interventions for early recognition and management of oncologic emergencies in adults with cancer. Oncologic emergencies represent time-critical conditions including neutropenic sepsis, malignant spinal cord compress [....] » Read More
Introduction: Patients with acute leukemia who experience neutropenia after intensive chemotherapy have a high risk of developing Invasive Fungal Infections (IFIs), which can be life threatening. Although diagnostics and supportive care have been enhanced, IFIs continue to be a m [....] » Read More
The early and precise diagnosis of melanoma plays a crucial role in improving survival rates and enabling timely intervention. However, automated melanoma detection systems face challenges due to image artifacts, illumination variation, and inter-class similarities. This study in [....] » Read More
Gaza faces unique challenges in providing cancer care due to ongoing conflict, resource limitations, and disruptions in healthcare infrastructure. As an oncology nurse, I have firsthand experience managing these challenges, particularly in delivering chemotherapy safely, monitori [....] » Read More
Gastric adenocarcinoma (GAC) remains one of the leading causes of cancer-related mortality worldwide, largely due to its late-stage diagnosis, limited treatment options, and poorly understood molecular drivers. Recent studies have implicated epigenetic dysregulation in GAC pathog [....] » Read More
Immune checkpoint inhibitors have marked a new era in contemporary cancer therapy. However, they are associated with a spectrum of immune-related adverse events (irAEs), including rare but severe neurologic toxicities (nirARs). Here, we report a case of acute inflammatory demyeli [....] » Read More
Title : Personalized and Precision Medicine (PPM) through the view of biodesign-inspired translational research: An option for clinical oncologists, caregivers, and consumers to realize the potential of genomics-informed care to secure human biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will pe [....] » Read More
Title : Updates on controversies surrounding the staging and management of newly diagnosed localized prostate cancer using Prostate-Specific Membrane Antigen (PSMA) positron emission tomography
Patricia Tai, University of Saskatchewan, Canada
Prostate cancer is a very common malignancy in men, particularly in the Western world, although its incidence is lower among Asians. It can be identified using the relatively new prostate-specific membrane antigen (PSMA) positron emission tomography (PET), a highly sensitive and [....] » Read More
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Background Drug resistance, including Adriamycin-based therapeutic resistance, remains a challenge in breast cancer (BC) treatment. Studies have revealed that macrophages could play a pivotal role in mediating the chemoresistance of cancer cells. Accumulating evidence suggests th [....] » Read More
Title : Discovery of an R-spondin–ALK–Wnt axis: Expanding the oncogenic landscape of anaplastic lymphoma kinase
Chockalingam S, National Institute of Technology Warangal, India
Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, has emerged as a critical driver of malignancy in diverse cancers such as anaplastic large cell lymphoma, non-small cell lung cancer, and neuroblastoma. Although ALK is normally activated by its ligands ALKAL1 and ALKA [....] » Read More
Title : A case-based approach using IMPeTUs criteria in FDG PET/CT reporting of multiple myeloma
Mudalsha Ravina, All India Institute of Medical Sciences, India
[18F]FDG PET/CT has become an integral component in the evaluation of Multiple Myeloma (MM), offering significant advantages in disease detection, staging, treatment response assessment, and prognostication. The Italian Myeloma criteria for PET Use (IMPeTUs) provide a standardize [....] » Read More
Title : A pioneering, first-of-its-kind Canadian off-site program designed to reduce the burden on hospital staff and optimize the use of space
Patricia Tai, University of Saskatchewan, Canada
Aim: Degarelix, a GnRH antagonist for ADT, showed remarkable results in clinical trials. We launched Canada’s first off-site injection program to decentralize services from overloaded acute care settings. This is the first reported Canadian community experience with degarel [....] » Read More
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
In this study we are the first worldwide to reveal a GP73-mediated regulatory network that promotes tumor angiogenesis and progression in Hepatocellular carcinoma (HCC) under hyperxia stress. Our findings demonstrated that GP73 plays crucial roles in tumor angiogenesis nich [....] » Read More
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China
Chemoresistance remains the predominant cause of treatment failure in osteosarcoma (OS), yet its underlying molecular circuitry remains poorly defined. To address this gap, we conducted a series of mechanistic and clinically informed studies integrating molecular biology, epitran [....] » Read More
Title : Bevacizumab versus anlotinib respectively combined with chemotherapy drug in the treatment of EGFR-TKI acquired resistant advanced lung adenocarcinoma
Yanyu Qi, Chengdu Third People's Hospital, China
Objective: To compare the short-term therapeutic efficacy and safety of bevacizumab versus anlotinib, each in combination with chemotherapy, for the treatment of advanced lung adenocarcinoma with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors ( [....] » Read More
Title : Personalized and precision oncology via integrating genomics, pathology-related modeling, and IT-assisted approaches to prevent, treat, and cure cancer and its complications
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Individualizing patient treatment is a core objective of the medical field. Meanwhile, the inherent variability of cancer illustrating the molecular differences between tumors, securing the linkages of those differences to an effective drug and resulting in immense patient benefi [....] » Read More
Title : Programmable enzyme–enabled ultra-sensitive liquid biopsy for early detection of tumor MRD
Jinzhao Song, Hangzhou Institute of Medicine, Chinese Academy of Sciences, China
Minimal residual disease (MRD) can persist in cancer patients even after potential cure, resulting in cancer recurrence and contributing to the low five-year survival rate of cancer patients. Currently, circulating tumor DNA (ctDNA) is the preferred biomarker for MRD detection. H [....] » Read More
Title : Intraocular lymphomas associated with primary CNS lymphomas: Great mystification. Clinical landscape and diagnostic challenges
Maria S Shmelkova, Burdenko National Research Neurosurgery Center, Russian Federation
Primary intraocular lymphomas (PIOL) or vitreoretinal lymphomas (VRL) are a type of primary central nervous system lymphoma (PCNSL), accounting for approximately 2–3% of all non-Hodgkin lymphomas and developing in about 11–25% of patients with PCNSL. Morphologic [....] » Read More
Title : A prospective study of tislelizumab combined with radiotherapy in unresectable or recurrent advanced hepatocellular carcinoma: Efficacy and immunological safety analysis
Han Sun, Liaoning Cancer Hospital & Institute, China
Background: Radiotherapy (RT) can induce immunogenic cell death and enhance tumor antigen release and presentation, thereby augmenting the host anti-tumor immune response. The combination of PD-1 inhibitor tislelizumab with RT may produce synergistic effects and improve outcomes [....] » Read More
Title : Phosphate analog PPF inhibits papillary thyroid cancer by disrupting phosphate balance and reprogramming tumor metabolism
Yuanhao Su, Second Affiliated Hospital of Xi'an Jiaotong University, China
Background: The global incidence of papillary thyroid cancer (PTC) has been increasing in recent years, placing greater demands on healthcare systems worldwide. While standard treatments such as surgery combined with radioactive iodine therapy and chemoradiotherapy are common, ma [....] » Read More
Title : Development and validation of a clinical decision-support model for preoperative individualized assessment of high-volume central lymph node metastasis in older adults (over 55 years) with papillary thyroid carcinoma
Yongke Wu, The Second Affiliated Hospital of Xi’an Jiaotong University, China
Background: Elderly patients with papillary thyroid carcinoma (PTC) constitute a unique subgroup in clinical practice, often exhibiting more aggressive tumor characteristics. Although current guidelines offer few specific recommendations for patients aged ≥55 years, it is vita [....] » Read More
Title : Evaluation of survival prognostic factors in different treatment modalities for locally advanced unresectable esophageal squamous cell carcinoma
Yanni Zhang, Liaoning Cancer Hospital & Institute, China
Background: Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), remains a leading cause of cancer-related mortality worldwide. This study investigates the impact of different treatment modalities, namely concurrent chemoradiotherapy (CCRT), chemoimmunothera [....] » Read More
Title : Pleural fluid C-C motif chemokine ligand 2: An effective biomarker for diagnosing malignant pleural effusion
Li Ma, Beijing Chest Hospital, China
Background: Accurate diagnosis of malignant pleural effusion (MPE) using biomarkers remains challenging. C-C motif chemokine ligand 2 (CCL2), a chemokine markedly overexpressed under pathological conditions, has emerged as a pivotal biomarker across various diseases and plays a k [....] » Read More
Title : BCL2A1 expression in CD8⁺ T cells is associated with survival and immune checkpoint blockade response in lung adenocarcinoma
Hoang Minh Quan Pham, Taipei Medical University, Taiwan
Background: Biomarkers associated with response to immune checkpoint blockade (ICB) in lung adenocarcinoma (LUAD) remain incompletely defined. This study examined the transcriptional landscape of BCL2A1 in CD8⁺ T cells and evaluated its association with clinical outcomes i [....] » Read More
Title : Unmasking the cytokine storm: A spectrum of paediatric hemophagocytic lymphohistiocytosis across immuno-oncologic, infectious, and genetic landscapes - insights from a tertiary oncology centre in South India
Megadeepan Senthilkumar, Kidwai Memorial Institute of Oncology, India
Background: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with heterogeneous triggers, ranging from genetic predispositions and immunodeficiencies to malignancies and infections. We report four paediatric cases highlighting the clinical spectrum, diagno [....] » Read More
Title : Targeting HSD11B2–PD-L1 axis: A novel strategy to reverse immune escape and spontaneous metastasis in renal cell carcinoma
He Haowei, Jinling Hospital, China
Background: Metastatic renal cell carcinoma (mRCC) remains a therapeutic challenge with poor prognosis, as current immunotherapy combinations often encounter resistance. Immune escape is a key driver of spontaneous metastasis; however, the underlying regulatory mechanisms in mRCC [....] » Read More
Title : Identification of prognostic biomarkers and potential therapeutic targets for lung cancer by metabolomics analysis
Li Su, Harvard T.H. Chan School of Public Health, United States
Rationale: Metabolic reprogramming is a hallmark of lung cancer and a source of druggable vulnerabilities. Bridging mechanistic metabolic signatures with clinical prognostication may reveal targetable pathways that inform precision therapy and biomarker guided trials. However, th [....] » Read More
Title : The oncogenic role of KCNN4 in renal clear cell carcinoma: A mechanism involving immune regulation via Tregs and resting mast cells
Xiaoming Yi, Jinling Hospital, China
Background: Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system, with clear cell RCC (ccRCC) representing its predominant subtype. The pathogenesis of ccRCC remains incompletely understood. KCNN4 (potassium calcium-activated channel subfamily N membe [....] » Read More
Title : Phytohormone strigolactams overcome oxaliplatin resistance in colorectal cancer by blocking late-stage autophagy to tip the metabolic balance toward ferroptosis
Xingyue Chen, Southeast University, China
My presentation addresses one of the most pressing challenges in oncology: Treatment Resistance. I will focus on a novel strategy to overcome oxaliplatin resistance in colorectal cancer, titled " Phytohormone strigolactams overcomes oxaliplatin-resistance in colore [....] » Read More
Title : Overcoming therapeutic resistance in oncology: A regioselective borylation platform for resurrecting and evolving nucleoside therapeutics
Yutong Zhou, Southeast University, China
The emergence of treatment resistance remains a central challenge in oncology, often stemming from the limited chemical diversity and predictable mechanisms of existing drugs. We present a transformative chemical strategy to combat this by creating novel nucleoside-boron hybrids [....] » Read More
Title : Temporal changes in HER2 and nectin4 expression in urothelial carcinoma: Implications for antibody–drug conjugate therapy
Fu Dian, Jinling Hospital, China
Background: Urothelial carcinoma is frequently managed with chemotherapy combined with immunotherapy or antibody-drug conjugates (ADCs) targeting HER2 and Nectin4, which have shown promising efficacy in clinical practice. However, treatment response often diminishes over tim [....] » Read More