Title : The role of biophysics in cancer
Abstract:
The proliferative biophysical structure is associated with Earth’s or Lunar time(183 or 777), Earth’s gravity(734) and Lunar gravity(0.1605 or 705) in context of 900-109(reverse) fundamental mathematical complex with a directional difference of 1 that would be responsible for cell signaling.
The Histidine(155.1552)-Tyrosine(181.1894) structural complex is associated with cancer biology where core values(Cv) of tyrosine = 181*0.0019 – 0.1894 = 0.1545 or 645 = 900 – 255 according to the formula Time = M*0.0019 derived from 14.0267, an inter-amino acid factor somewhere and M is the integer mass can be transformed into time. Towards evaluation of mutational values in cancerous point mutations core values are important.
The Osimertinib(499.619g/mol), a tyrosine kinase inhibitor can be derived from tyrosine core values where 645 – 255 = 390(neutral point) and 390 + 109 = 499(reverse of 994) and 390 – 109(downstream) = 281 = 900 – 619(i.e. 705*2 + 109 are also chemical components) causing the drug in the structure.
Considering histidine structure, 559 – 155 = 404 or 319 where 31*13 = 403 with a directional difference of 1. Histidine possesses a bisectional infrastructure where 0.1552 or 652*2 = 1304 or 404 and 248*2 = 496(i.e. 289) linked to tyrosine. It is seen 559 + 496 = 1055 or 155 and 403 – 319 = 84 = 652 – 568(i.e 734*2) and conversely 403 + 319 = 722 = 900 – 178 where 568 + 510(i.e. 705*2) = 1078 or 178 under suppression.
A blocking of oxy-time(329 or 239) has been found in the system towards mutation. Oxy-therapy might be a process in cancer treatment needed investigations. Structurally, 155 + 84 = 239 and correspondingly 652 + 84 = 736(i.e. 32*23)= 900 – 164(i.e.955) and 248 – 84 = 164(i.e. 329 = 164*2 + 1) and also 107(would be influx of electro-gravitational wave) + 48(reverse of 84) = 155 in the structure.
In JAK2 G1849T V617F or TP53 G469T V157F, the mutational values 151(G) – 126(T) = 25 or 0.0475 and 1235(phe Cv) – 754(val Cv) = 481 = 900 – 419 where 41*14 = 574(reverse of 475) avoiding decimals and negative mark. It is seen 481 + 93 = 574 where 652 – 93 = 559 and 248 – 93 = 155. Mathematically, 107(influx of electro-gravitational wave in the system) + 93 = 200 = 481 – 281 and 619 – 200 = 419 that related to tyrosine.
In EGFR lung cancer mutations, L858R and C797S are two anti-parallel mutations that shows 1289(R Cv) – 753(L Cv) = 536 and 1065(S Cv) – 709(C Cv) = 356 where 536 + 3 = 539 = 734 + 705 = 900 -361 and 356 + 3 = 359 and where 539 – 359 = 180 = 183 – 3 in the structure. Now, 53*35 = 1855 or 955 where 55 + 109 = 164(reverse of 361) = 107 + 57(3) in the structure.
