Precision oncology uses molecular and clinical information to select the most effective therapies while minimizing unnecessary toxicity. Genetic testing identifies inherited cancer predispositions andtumor-specific mutations, enabling earlier detection, more accurate prognosticat… » Read More
Biomarker based detection for ovarian cancer (OC) in clinical settings is currently focused on the biomarker CA-125. This marker unfortunately has a fairly low sensitivity and specificity for ovarian cancer at only 82% and 67% respectively. It is also lacking in stage I ovarian c… » Read More
Fluorine-decorated graphene quantum dots (F@GQDs) will be herein explored as a material platform for application in photodynamic therapy (PDT). GQDs have been extensively studied in biomedical areas such as bioimaging, bio-sensing and photothermal therapy due to their superior op… » Read More
The prognosis of breast cancer remains unpredictable despite of frequent change in treatment protocol since last few decades. As we understand the heterogenous nature of the disease, complex tumor biology etc. the treatment protocols have changed. There is an unprecedented transf… » Read More
During mitosis sister chromatids are accurately segregated into two daughter cells through a microtubule-based structure known as the mitotic spindle. Mitotic spindle assembly is a crucial machinery of cell proliferation that ensures the maintenance of genome integrity in eukaryo… » Read More
Objectives: Human papillomavirus (HPV) is the major etiological agent of cervical cancer, a leading cause of morbidity and mortality in women worldwide; screening strategies for reducing the burden of HPV-mediated carcinogenesis are emerging as effective means for cervical cancer… » Read More
The fundamental values in the system 87 + 250 = 337 = 338(i.e. 676/2) -1 where ‘1’ is about common in the system and 900 – 676 = 224 and 676 – 224 = 452 = 561 – 109 in structural complex. In pathways, 777(lunar time) – 439 = 338 should meet to 349 and 34*43 = 562(under suppressio… » Read More
Background: KRAS G12D is one of the most prevalent oncogenic drivers in pancreatic and colorectal cancers and remains a challenging therapeutic target because of its high affinity for GTP and the absence of a reactive residue for covalent inhibition. Identifying non-covalent inhi… » Read More
Scientific program for this day is coming soon.
Title : Long-read sequencing reveals dynamic features of human malignancies
Jianhua Luo, University of Pittsburgh School of Medicine, United States
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. Genetic mutation is essential in species evolution and cancer development. Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein exp… » Read More
Title : Nanomedicine in over 45,000 patients and no cancer
Thomas Jay Webster, Brown University, United States
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of US FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For … » Read More
Title : Personalized and Precision Medicine (PPM) through the view of biodesign-inspired translational research: An option for clinical oncologists, caregivers and consumers to realize the potential of genomics-informed care to secure human biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare ser-vices, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based med-icine and thus genomics biomarkers promises to provide molecular tests that will … » Read More
Title : Personalized and precision medicine as a unique avenue to have the healthcare model renewed to secure national biosafety: To get cancer treated or cured?
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
To achieve the implementation of Personalized & Precision Oncology (PPO), it is necessary to create a fundamentally new strategy based upon the recognition of biomarkers long before the disease clinically manifests itself. And personalized tumor molecular profiles (uniting genomi… » Read More
Title : Tumor resectability and pathologic response after neoadjuvant long-course chemoradiotherapy for locally advanced rectal cancer in a resource-limited setting
Samrawit S Halake, Kampala International University, Uganda
Purpose: In resource-limited settings, locally advanced rectal cancer (LARC) often presents at advanced stages. Long-course chemoradiotherapy (LCCRT) remains a cornerstone of neoadjuvant therapy, yet outcome data from such settings remain limited. This study assessed tumor resect… » Read More
Title : Horizon Spectra: A comprehensive cancer genomics tertiary platform for ultra-rapid analysis
Mohammed Uddin, GenomeArc Inc, Canada
Horizon is an integrated, ultra-fast genomic intelligence platform designed to streamline and enhance precision oncology workflows. The software delivers end-to-end analytical capabilities spanning somatic and germline variant interpretation, tumor profiling, and molecular diagno… » Read More
Title : Reovirus inhibits tumor antigen presentation leading to impaired cytotoxic-T responses
Raghad Khaleafi, Technion-Israel Institute of Technology, Israel
Oncolytic viruses are an emerging class of cancer immunotherapies, with several agents approved for clinical use. Mammalian reovirus-based therapies are currently being evaluated in numerous clinical trials, commonly in combination with other immunotherapies such as immune checkp… » Read More
Title : Impact of normalization strategies on the diagnostic performance of salivary microRNAs for early detection of oral squamous cell carcinoma: A systematic review, diagnostic meta-analysis, and meta-regression
Jamal Khan, Khyber College of Dentistry, Pakistan
Salivary microRNAs (miRNAs) are promising non-invasive biomarkers for the early detection of oral squamous cell carcinoma (OSCC), but variability in normalization strategies limits their reproducibility and clinical translation. This PRISMA-guided systematic review (PROSPERO: CRD… » Read More