Abstract
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Objective: Oxygen-enriched oleic matrix dressings — ozonated olive oil releasing reactive oxygen species — are used on postoperative wounds, yet their role in the head and neck is undefined.
Methods: Scoping review of PubMed and Europe PMC (18 September 2026) covering this device class and related ozonated oils at head and neck sites; design, endpoints and safety were extracted, without risk-of-bias scoring. We also describe five consecutive cervicofacial wounds managed with the device at our centre.
Results: Four randomised trials of the device class exist: versus a silver dressing in chronic colonised wounds (n = 81; area −60.9% vs −38.7%), after third molar extraction (n = 71; VAS 3.57 vs 4.47, p = 0.0014), after hypospadias repair (n = 114) and in hidradenitis (n = 25; no difference). District evidence is confined to oral mucosa and perioral skin, and a trial of highly ozonated oil on palatal wounds showed no benefit. No controlled study addressed cervicofacial surgical wounds, irradiated skin, flaps or tumour wounds.
Conclusions: Extrapolation is legitimate by wound phenotype and care model, not by numerical expectation. We propose a format-to-scenario pathway and a study with time to adjuvant treatment as primary endpoint.
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