The future of pharmacogenetic polymorphism, pharmacogenomics and pharmamicrobiome in cancer treatment

Drug metabolism is crucial in any functioning of a drug, particularly in drugs for cancer treatment. Several drugs do not function in human body in their original state unless metabolised to its required functioning metabolite to affect its target organ/site or tissue. Drug metabolism occurs via certain drug metabolising enzymes and transporters which are responsible for drug biotransformation and function. The increasing understanding of the implications of genetic variation, genomics, and microbes in disease, is paramount in identifying and validating clinically relevant biomarkers to improve patient outcomes during chemotherapy.

The human genome has variation occurring in every 300-1000 nucleotides, with over 14 million single nucleotide polymorphisms (SNPs) across the entire genome. The individual differences in traits, characteristics and behaviour can determine patients’ response administered with same drug.

Conclusion: To reduce toxicity and improve efficiency of therapy, it is crucial to understand variations in genetics and genomic that impacts on drug response, to optimize cancer therapy and individual side effects. Researchers have intensely focused on human genomes and genetics; understanding the roles of microbiome in drug metabolism and function, could further define patient’s response to therapy?

Bene is a graduate of River State University of Science & Technology in Applied Biology (Medical Microbiology option); with an MRes degree at University of East London, United Kingdom. She had her PhD study & worked at the Department of Natural Sciences, Middlesex University, UK. Trained in practical approach to toxicology in drug development (American College of Toxicology/British Toxicology Society). Bene had Harvard University part-sponsored training in Cancer Biology & Therapeutic, and received a 2nd Harvard award for a complementary training in COVID-19 and Mental Health for Medical Professionals. Bene has her expertise in evaluation and passion in improving the health and wellbeing. Her open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. Researching in Microbiology, Molecular Biology and Cancer: Her current focus of research (which has yielded eight designed drug models), is on the Investigation of molecular mechanism of colorectal cancer and due to the year 2020 pandemic, has been involved in drug development for COVID-19; she set up a diagnostic laboratory for COVID-19 testing service, and now expanding diagnostic scope. Bene has been speaking in several conferences and published over seven peer reviewed articles, as well as written a chapter in Springer Nature book series on Cancer & Immunology. And a manuscript on COVID-19 was submitted to the Chief Medical Officer of United Kingdom to assist in response to the pandemic. Bene sits on journals’ editorial boards, and review panels. Bene sits on congress’ committee Board (European Congress on Human Genetics 2024, Oncology & Cancer Conference 2024). She is expanding through her years of research evaluation and teaching to establish Hospital projects in Africa, starting with Nigeria’s state-of-the-art Hospital project. Bene is the Founder & CEO of ZEAB Therapeutic LTD, UK, ZEAB Medical Centre, Lagos Nigeria; as well as the founder of two non-profit organizations: Citizen’s Wellbeing Intervention UK, and Earthwise & Citizens’ Empowerment Nigeria. She was recently endorsed by and in collaboration with the Ministry of Environment Nigeria for promotion of transition to Green Renewable system. She is a member of the Medical Research group council at University of East London, a research consultant with Norxin Medical research Cooperation. She is honoured with an affiliation to Universal Scientific Education & Research Network (USERN), London, England United Kingdom. Bene is also involved in advocating for liveable environment; with recent approval for National Summit on Green-Renewable Energy & Climate in Nigeria by President of Nigeria.