Abstract:
Background Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide.1 It is the second most common cancer diagnosed in women and third most in men. In women, incidence and mortality are approximately 25% lower than in men. These rates also vary geographically, with the highest rates seen in the most developed countries . With continuing progress in developing countries, the incidence of colorectal cancer worldwide is predicted to increase to 2·5 million new cases in 2035.
Methods Two hundreds a histopathologically confirmed colorectal cancer cases were recruited from Tanta university oncology department. 150 patients matched with age ,sex and social class were recruited as control group.
Results Multivariable conditional logistic regression model showed that cases were 3.9 times more likely to have had attainted obesity (BMI ≥ 30) in their lifetime compared to controls (OR= 3.9; 95% CI: 1.8–10.6). Compared to controls, cases rarely consumed fruits and vegetable OR = 16.9; 95% CI: 6.5–48.5), tended to consume red meat 2-5 times a week (OR= 4.7; 95% CI: 1.8–8.8) or more than 5 times a week (OR = 10.8; 95% CI: 4.5–26.9).).
Conclusions Obesity, excessive red meat consumption and infrequent consumption fruits/vegetables intake were associated with an increased risk of colorectal cancer.
