Title : Bioscope: A new instrumental approach for early diagnosis of oncological diseases
Abstract:
Modern medical methods of treatment allow in some cases to prevent the development of pathological processes in the human body. It is known that the effectiveness of such therapeutic effects is largely determined by the possibility of diagnosing the disease at the initial stages of its development. In particular, statistics show that when cancer is detected at an early stage, the probability of cure is 90-95%. In later stages, this figure drops to 50%, and in the third and fourth stages, the probability of cure is only 10-12%.
The foregoing makes it relevant to search for new and more sensitive instrumental approaches to the formation of oncological formations. In this regard, the “Bioscope” hardware complex developed in our laboratory is of particular interest.
The device is simple in design, and the principle of its operation is based on the estimation of the intensity of light scattered in an opaque chamber from a glass plate covered with a thin opaque material (e.g.black rough paper). Different biological objects located at some distance from the device affect the readings of the "Bioscope" in varying degrees; at the same time, the signals of the equipment also change when the physiological state of the studied system changes. This indicates the possibility of using the "Bioscope" to assess the state of the biological system in various biomedical studies.
In experiments with artificial infection of mice with skin cancer, it was shown that already one day after lethal infection with skin cancer, a pronounced "cancer peak" is formed in the spectral distribution of the "Bioscope" signals, which remains until the death of the mice. In mice that were also infected with skin cancer, but did not die, the "cancer peak" was practically not formed.
At the same time, in experiments with people, an interesting fact was revealed: the patient complained of discomfort in the area of the right mammary gland. Mammographic examination did not reveal any pathology. Nevertheless, the "Bioscope" signals indicated a sharp difference in the states of the right and left mammary glands. After 2 months, using conventional instrumental tools, the onset of neoplasm development in the right mammary gland was confirmed.
The presented results indicate, that after testing on a larger number of patients, the "Bioscope" device create prerequisites for its use as a new diagnostic tool and for early detection of the onset of oncological diseases.
