Abstract:
Poly(lactic-co-glycolic acid) (PLGA) nanoparticle has proven extremely useful for drug delivery, thanks to its high biocompatibility, biodegradability, and toxicologically safe degradation products. This talk will emphasize the use of nanosized (~140 nm mean diameter) PLGA loaded with selol and maghemite nanoparticles (~9 nm mean diameter). The platform comprising selol-maghemite-loaded PLGA nanoparticles is very promising for solid tumor growth hindering in combination with magnetohyperthermia. The effectiveness of using the as-fabricated selol-maghemite-loaded PLGA nanoparticles (NcSel) associated with different tumor treatment protocols will be explored. One-week treatment of combined therapy comprising magnetic hyperthermia and selol-loaded nanoparticles in reduced dosages is able to hinder primary breast tumor growth in aged animal model. Moreover, different biological observations are in excellent agreement with the parameters extracted from the logistic modelling. Importantly, biocompatibility analyses revealed that the adverse effects of the treatments are negligible. Taken together, the results herein reported lead us to suggest the translation of this nanotherapeutic approach for future clinical trials. In short, the use of NcSel plus MHT as a short-term neoadjuvant therapy, for example, may represent a less costly, safe and effective alternative in cancer control in aged patients. It is also expected that the shorter treatment period will contribute to the adherence of cancer patients.
Biography:
Paulo C. DE MORAIS (H-61), PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013, Appointed as UnB’s Emeritus Professor (2014), Appointed as Guest Professor of Huazhong University of Science and Technology – China (2011), Visiting Professor at Huazhong University of Science and Technology (HUST) – China (2012-2015), Appointed as Distinguished Professor at Anhui University (AHU) – China (2016-2019), Appointed as Full Professor at Catholic University of Brasília (UCB) – Brazil (2018), Appointed as CNPq-1A Research Fellowship since 2010. 2007 Master Research Prize from UnB, 2008-member of the European ERA NET Nanoscience Committee, Member of the IEEE-Magnetic Society Technical Committee, Senior Member of the IEEE Society, 2012 China’s 1000 Foreign Expert Recipient, and 2012 Academic Excellence Award from Brazilian Professor’s Union. He held two-years (1987-1988) post-doc position with Bell Communications Research – New Jersey, USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais – Brazil. He graduated in both Chemistry (1976) and Physics (1977) at UnB. Professor Morais is member of the Brazilian Physical Society and the Institute of Electrical and Electronics Engineers – IEEE. He has served as referee for more than 50 technical journals, takes part of the Editorial Board of more than 15 technical journals and has conducted research on nanomaterials for over 40 years. He is known for his research in preparation, characterization and applications of nanosized materials (magnetic fluid, magnetoliposome, magnetic nanoemulsion, magnetic nanocapsule, magnetic nanofilm, magnetic nanocomposite, nanosized semiconductors, polymeric dots, carbon dots, and graphene quantum dots). With more than 500 published papers in peer reviewed journals, more than 14,000 citations, more than 250 international invited talks (35 countries), and 16 filed patents. He has appeared in recent World ranking of top scientists, such as 2020-Stanford, 2022-Research.com, 2023-AD Scientific Index, 2023-Research.com, 2024-Elsevier, 2025-AD Scientific Index, 2025-Research.com, and ONE Research Community.
