Successful tumor growth control using PLGA nanoparticles loaded with selol and nanomaghemite

Title : Successful tumor growth control using PLGA nanoparticles loaded with selol and nanomaghemite

Abstract:

Poly(lactic-co-glycolic acid) (PLGA) nanoparticle has proven extremely useful for drug delivery, thanks to its high biocompatibility, biodegradability, and toxicologically safe degradation products. This talk will emphasize the use of nanosized (~140 nm mean diameter) PLGA loaded with selol and maghemite nanoparticles (~9 nm mean diameter). The platform comprising selol-maghemite-loaded PLGA nanoparticles is very promising for solid tumor growth hindering in combination with magnetohyperthermia. The effectiveness of using the as-fabricated selol-maghemite-loaded PLGA nanoparticles (NcSel) associated with different tumor treatment protocols will be explored. One-week treatment of combined therapy comprising magnetic hyperthermia and selol-loaded nanoparticles in reduced dosages is able to hinder primary breast tumor growth in aged animal model. Moreover, different biological observations are in excellent agreement with the parameters extracted from the logistic modelling. Importantly, biocompatibility analyses revealed that the adverse effects of the treatments are negligible. Taken together, the results herein reported lead us to suggest the translation of this nanotherapeutic approach for future clinical trials. In short, the use of NcSel plus MHT as a short-term neoadjuvant therapy, for example, may represent a less costly, safe and effective alternative in cancer control in aged patients. It is also expected that the shorter treatment period will contribute to the adherence of cancer patients.

Biography:

Professor Paulo César De Morais (H60), PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013. Appointed as UnB’s (Brazil) Emeritus Professor (2014); Visiting Professor at the Huazhong University of Science and Technology (HUST) – China (2012-2015); Distinguished Professor at the Anhui University (AHU) – China (2016-2019); Full Professor at the Catholic University of Brasília (CUB) – Brazil (2018); CNPq-1A Research Fellow since 2010; 2007 Master Research Prize from UnB. He held two-years (1987-1988) post-doc position with Bell Communications Research, New Jersey – USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais (UFMG) – Brazil. With more than 13,000 citations, He has published more than 500 papers (Web of Science), delivered more than 200 international invited talks, and filed 16 patents.