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International Cancer Research Conference

March 24-26, 2025 | Singapore

March 24 -26, 2025 | Singapore

Biology of Cancer

Biology of Cancer

Cancer is a genetic disorder in which the information in cellular DNA is distorted, resulting in aberrant gene expression patterns. As a result, normal genes that control normal cellular processes like growth, survival, and invasion/motility are amplified, whereas genes that inhibit these effects are suppressed. Although non-mutational (epigenetic) alterations produced by mechanisms such as DNA methylation are becoming recognized as crucial to the process, the accumulation of mutations is the major mechanism of alteration. The so-called hallmarks and enabling characteristics of cancer are basic alterations in biological processes within cancer cells caused by abnormal gene expression. Eight distinct hallmarks and two additional so-called enabling traits can be used to understand cancer's biological behavior. In cancer medicine, a better understanding of the biological basis of these processes has transformed diagnosis, treatment and prognosis.

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