Cancer neoantigens are novel peptides presented by cancer cells that arise from tumor-specific mutations. Unlike normal cellular proteins, these neoantigens are recognized as foreign by the immune system, making them promising targets for cancer immunotherapy. Neoantigen-based therapies, such as personalized cancer vaccines and adoptive T-cell transfer, aim to harness the body’s immune response to selectively attack tumor cells while sparing healthy tissue. Recent advances in genomics and bioinformatics have accelerated the identification and validation of neoantigens, paving the way for highly individualized treatments. These therapies hold potential for improved efficacy and reduced toxicity compared to traditional cancer treatments, marking a significant advancement in personalized oncology.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China