Aging is a significant risk factor for cancer, with most diagnoses occurring in older adults. As we age, genetic mutations accumulate, and immune system efficiency declines, increasing cancer susceptibility. Cellular senescence, an aging hallmark, promotes a pro-inflammatory environment, contributing to tumor development.
For older patients, cancer treatment poses unique challenges. Comorbidities and reduced physiological reserves often limit the feasibility of aggressive therapies. Advances in geriatric oncology are now tailoring treatments to the specific needs of aging individuals, focusing on balancing efficacy and quality of life.
Studying the interplay between cancer and aging not only enhances understanding of disease progression but also drives innovations in early detection, prevention, and personalized care for an aging global population.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China