Acute Myeloid Leukemia (AML) is a rapid-progressing hematologic malignancy characterized by the uncontrolled proliferation of immature myeloid cells. Current cancer research focuses on understanding the genetic and molecular basis of AML to develop targeted therapies. Advances in genomics have identified mutations in genes such as FLT3, NPM1, and DNMT3A, providing insights into disease pathogenesis and potential therapeutic targets. Novel treatments, including FLT3 inhibitors and immune-based therapies like monoclonal antibodies and CAR-T cells, are under investigation. Additionally, researchers are exploring the role of the bone marrow microenvironment in AML progression and resistance to therapy, aiming to improve patient outcomes through personalized medicine.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China