The tumor microenvironment (TME) is a dynamic and complex ecosystem surrounding cancer cells, composed of stromal cells, immune cells, blood vessels, and extracellular matrix components. These elements interact with tumor cells to influence cancer progression, metastasis, and resistance to therapies. The TME plays a critical role in supporting tumor growth by providing nutrients, promoting immune evasion, and enhancing cell migration. Additionally, cancer cells can manipulate the TME to create a favorable environment for their survival. Understanding these interactions has led to new therapeutic approaches aimed at disrupting the TME. For example, targeting the blood vessels that supply tumors with oxygen and nutrients or modulating immune cells to enhance anti-cancer immunity are promising strategies. Research into the TME also focuses on understanding how cancer cells manipulate the surrounding tissues to create a protective niche, which could provide insights into novel treatment options that target the environment as well as the cancer cells themselves.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China