Genetic syndromes that increase the risk of childhood cancers provide essential insights into the genetic mechanisms that drive tumor formation. Syndromes like Li-Fraumeni, neurofibromatosis, and retinoblastoma are associated with a higher incidence of pediatric cancers due to inherited mutations that affect tumor suppressor genes or DNA repair mechanisms. Studying these conditions helps researchers better understand the genetic mutations that predispose children to cancers, allowing for earlier detection and intervention strategies. Furthermore, identifying the genetic basis of these syndromes aids in the development of targeted treatments tailored to the specific molecular characteristics of each condition, offering potential for more effective and personalized therapies for pediatric cancer patients.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China