Clinical trial design plays a crucial role in the development of new cancer treatments. Innovations in trial methodologies are constantly evolving to address challenges such as patient recruitment, diversity, and the accuracy of results. Modern clinical trials increasingly utilize adaptive designs, where treatment protocols can be adjusted based on interim data, allowing for quicker conclusions and more efficient use of resources. Additionally, the use of precision medicine in trials ensures that therapies are tailored to individuals based on genetic profiles, improving the likelihood of success. Innovative patient recruitment strategies, such as digital platforms and remote monitoring, enhance access and ensure diverse representation, making trials more inclusive. The ongoing evolution of clinical trial design, along with advancements in trial monitoring and data analysis, is key to testing new therapies faster and more effectively, ultimately advancing cancer care and treatment outcomes.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China