Cancer genome sequencing projects represent a significant leap in understanding the genetic foundations of cancer. By analyzing the DNA of various cancer types, these efforts have identified mutations that drive tumor development and progression. Large-scale initiatives like The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) have mapped numerous cancer genomes, offering invaluable insights into oncogenes, tumor suppressor genes, and the complex interplay of genetic pathways. These findings have led to the development of targeted therapies, improving treatment outcomes. Moreover, integrating genomic data with clinical information allows for the classification of tumors into molecular subtypes, enabling personalized treatment plans. As technology advances, researchers are delving deeper into non-coding regions of the genome and rare mutations, uncovering previously hidden aspects of cancer biology. These discoveries are pivotal in designing innovative diagnostic tools, refining therapeutic approaches, and ultimately improving patient survival rates.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China