Mechanisms of Cancer in the Aging Population

Cancer incidence increases with age, with several mechanisms contributing to the heightened risk in older populations. Aging-related factors such as cellular senescence, impaired immune response, and accumulated DNA damage play crucial roles in cancer development. Furthermore, age-related changes in the tumor microenvironment, including chronic inflammation and reduced tissue repair, create a more favorable environment for cancer initiation and progression. Understanding the interplay between aging and cancer is essential for identifying age-specific therapeutic strategies that address the unique biological aspects of cancer in older adults, ultimately improving outcomes for this vulnerable group.