Innovative clinical trial designs in oncology are essential for advancing cancer treatments and improving patient outcomes. Traditional clinical trial models can be time-consuming and costly, often failing to account for the diverse genetic and environmental factors that influence cancer progression. In response, researchers are developing more adaptive and flexible trial designs, such as basket trials, umbrella trials, and platform trials. These approaches allow for the evaluation of multiple treatments across various cancer types, improving efficiency and enabling the rapid identification of effective therapies. Additionally, incorporating biomarkers into trial designs can ensure that patients receive treatments tailored to their specific genetic profiles. These innovative clinical trial designs not only accelerate the development of new cancer treatments but also ensure that they are more effective and personalized.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China