Epigenetic Changes in Aging and Cancer

Epigenetic changes are increasingly recognized as key contributors to both aging and cancer. These modifications, including DNA methylation, histone modification, and non-coding RNA expression, can alter gene expression without changing the underlying DNA sequence. In aging, epigenetic alterations accumulate, leading to disrupted cellular function and increased cancer susceptibility. Similarly, in cancer, epigenetic changes can activate oncogenes or silence tumor suppressor genes, promoting cancer progression. Targeting epigenetic pathways offers a promising strategy for both preventing age-related diseases and developing novel cancer therapies, as it allows for the reprogramming of cellular behavior at the molecular level.