Bleomycin, a chemotherapy agent, has been a cornerstone in cancer treatment since its discovery in the 1960s. It operates by disrupting DNA replication, leading to cancer cell death. Particularly effective against testicular cancer, Hodgkin's lymphoma, and squamous cell carcinomas, its use extends to various malignancies. However, its efficacy is tempered by significant pulmonary toxicity, a unique challenge in its administration. Research efforts have focused on strategies to mitigate this side effect, such as dose adjustments and pulmonary function monitoring. Additionally, studies explore combining bleomycin with other drugs to enhance its anticancer effects while minimizing pulmonary damage. As research advances, optimizing bleomycin's therapeutic potential remains crucial in improving cancer outcomes while managing its adverse effects.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China