Bacteria are single-celled organisms that are extremely small. Although the majority of bacteria are harmless, some can infect people and cause diseases. A few have even been linked to the development of cancer. Apart from inducing cancer by interfering with the host's normal defense mechanisms such as inflammation and antigen recognition, some bacteria have been found to produce tumor proteins as a result of metabolic products, which have direct myogenic or mutagenic effects.
Despite the fact that traditional cancer treatments remain the most prominent, bacterial therapy has demonstrated significant results due to its high specificity, ability to control after ingestion, and presence in several live experiments. Because of its tumor selectivity and large gene packaging capability, bacteria targeting tumors is an ideal strategy to administer therapeutic treatments.
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Title : Deubiquitylase USP31 induces autophagy and promotes the progression in lung squamous cell carcinoma cells by stabilizing E2F1 expression
Qian Zhang, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, China
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Luca Roncati, University of Modena and Reggio Emilia, Italy
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Bene Ekine-Afolabi, ZEAB Therapeutic Ltd, United Kingdom
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K.P.Mishra, Asian Association for Radiation Research, India