Ovarian germ cell tumors (OGCTs) are a rare subset of ovarian cancers, originating from the primitive germ cells of the embryonic gonad. They primarily affect adolescents and young women, often presenting with abdominal pain and masses. Research advancements have significantly improved the prognosis for OGCTs, with multimodal treatments combining surgery and chemotherapy proving highly effective. Chemotherapeutic regimens, particularly those including platinum-based compounds, have shown high cure rates even in advanced stages. Ongoing studies focus on minimizing treatment-related toxicity and exploring the molecular genetics of OGCTs to develop targeted therapies. Innovations in fertility preservation are also enhancing quality of life for survivors, addressing a critical concern for this young patient demographic.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China