Kaposi Sarcoma

Kaposi sarcoma (KS) is a rare cancer that often manifests as lesions on the skin, mucous membranes, or internal organs. Historically associated with HIV/AIDS, KS can also occur in transplant recipients and elderly individuals. Recent research in cancer biology has shed light on the role of human herpesvirus 8 (HHV-8) in KS development, particularly in immunocompromised individuals. Immunotherapy, including checkpoint inhibitors, shows promise in treating advanced KS by bolstering the body's immune response against HHV-8-infected cells. Additionally, targeted therapies that inhibit angiogenesis, a process crucial for tumor growth, are being explored as potential treatments for KS. While advancements have improved outcomes for KS patients, further research is essential to develop more effective and targeted therapies, especially for those with advanced disease or limited treatment options.