Gastrointestinal stromal tumors (GISTs) present a unique challenge in cancer research due to their rarity and diverse genetic makeup. While GISTs are relatively uncommon compared to other gastrointestinal cancers, they exhibit significant heterogeneity in their molecular characteristics, leading to variations in treatment response and outcomes. Recent advancements in cancer research have unveiled key molecular drivers behind GIST development, such as mutations in the KIT and PDGFRA genes, paving the way for targeted therapies like imatinib. However, resistance to these treatments remains a concern, driving ongoing efforts to elucidate alternative therapeutic strategies and biomarkers for predicting treatment response. Collaborative interdisciplinary approaches combining genomic profiling, immunotherapy, and novel drug development are essential for improving outcomes and addressing the complex nature of GISTs in the realm of cancer research.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China