Cancer xenografts are a cornerstone of cancer research, involving the transplantation of human tumor cells into immunodeficient mice. This model allows scientists to study tumor growth, progression, and response to treatments in a controlled environment that closely mimics human physiology. By implanting human cancer cells into mice, researchers can observe how tumors develop, metastasize, and interact with the host immune system. Furthermore, xenograft models enable the testing of potential therapies, such as chemotherapy drugs or immunotherapies, providing valuable insights into their efficacy and potential side effects before clinical trials in humans. Despite their limitations, such as the lack of a functional human immune system in the mouse host, cancer xenografts remain a vital tool in advancing our understanding of cancer biology and developing novel therapeutic strategies.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China