Cancer Xenografts

Cancer xenografts are a cornerstone of cancer research, involving the transplantation of human tumor cells into immunodeficient mice. This model allows scientists to study tumor growth, progression, and response to treatments in a controlled environment that closely mimics human physiology. By implanting human cancer cells into mice, researchers can observe how tumors develop, metastasize, and interact with the host immune system. Furthermore, xenograft models enable the testing of potential therapies, such as chemotherapy drugs or immunotherapies, providing valuable insights into their efficacy and potential side effects before clinical trials in humans. Despite their limitations, such as the lack of a functional human immune system in the mouse host, cancer xenografts remain a vital tool in advancing our understanding of cancer biology and developing novel therapeutic strategies.