Overcoming drug resistance in cancer treatment stands as a paramount challenge in the realm of oncology research, hindering the efficacy of numerous therapeutic avenues. Tumors exhibit resilience through diverse mechanisms, encompassing genetic alterations, alternative pathway activation, and interactions within the tumor microenvironment. Unlocking the complexities of drug resistance is pivotal for fostering novel treatment modalities. Researchers are actively exploring synergistic drug combinations, immunotherapeutic interventions, and precision-targeted therapies to surmount resistance barriers and enhance patient outcomes. Furthermore, breakthroughs in genomic profiling and single-cell analysis are unraveling intricate resistance mechanisms, propelling the development of personalized therapeutic regimens tailored to individual molecular signatures. Confronting cancer drug resistance head-on is indispensable for ushering in a new era of more potent and enduring cancer treatments.
Title : A novel blood-based mRNA genomics technology for cancer diagnosis and treatment
Rajvir Dahiya, University of California San Francisco, United States
Title : tRNA-derived fragment 3′tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer
Feng Yan, The Affiliated Cancer Hospital of Nanjing Medical University, China
Title : Integrating single-cell and spatial transcriptomics to uncover and elucidate GP73-mediated pro-angiogenic regulatory networks in hepatocellular carcinoma
Jiazhou Ye, Guangxi Medical University Cancer Hospital, China
Title : Unveiling the synergism of radiofrequency therapy and graphene nanocomposite in tumor cell viability assay
Paulo Cesar De Morais, Catholic University of Brasilia, Brazil
Title : Analysis of the dynamic evolution and influencing factors of nutritional risk in breast cancer patients during treatment
Jingwen Yan, Sun Yat-sen University, China
Title : Integrative multi-omics reveals metabolic–stemness coupling and novel therapeutic targets in osteosarcoma chemoresistance
Jinyan Feng, Tianjin Medical University Cancer Institute and Hospital, China