Breast papillary lesions exhibit broad range. Tajima et al. reported in discrimination between benign intraductal papilloma (IDP) and malignant endocrine ductal carcinoma in situ (E-DCIS), new marker of CD56 is useful for discriminating between benign and malignant. Hence, detect [....] » Read More
Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of act [....] » Read More
Ovarian cancer is the leading cause of gynecological malignancy-related deaths. Current therapies for ovarian cancer do not provide meaningful and sustainable clinical benefits, highlighting the need for new therapies. We show that the histone H3K79 methyltransferase disruptor of [....] » Read More
Poly (ADP-ribose) polymerase inhibitor (PARPi) -induced synthetic lethality of BRCA-deficient cells is being utilized to treat breast and ovarian tumors. However, emergence of resistance to PARPi remains a major concern and understanding resistance mechanisms is of utmost clinica [....] » Read More
Aim: Locally advanced rectal cancer (LARC) is treated by neoadjuvant chemoradiotherapy (NCRT) followed by surgery after restaging with magnetic resonance imaging (MRI). Texture analysis (TA) is an imaging biomarker that could assess MRIs heterogeneity by measuring grey-level [....] » Read More
The adaptation of CAR-therapy for a treatment of solid malignant tumors is currently considered as a highly promising opportunity for future therapies. One of the approaches in primary human T cell engineering effective commonly used for CAR gene delivery is retroviral gene trans [....] » Read More
As chemotherapy has advanced in recent years, 10-year survival of breast cancer patients has become as high as 79.3% in Japan. However, the prognosis of patients may be hampered by cardiotoxicity of anti-cancer treatment. It is known that Anthracyclines and Trastuzumab cause some [....] » Read More
Presentation will be about cancer drugs market which is popular for the treatment.
In the pediatric age group, Wilms Tumor (Nephro blastoma), is the commonest (85%). The others being Congenital Mesoblastic Nephroma, Clear Cell Sarcoma and Rhabdoid Tumor. Wilms Tumor is a Malignant Embryonal Tumor arising from the Nephrogenic blastema and has 3 components bla [....] » Read More
Cancers of the lip, oral cavity, hypopharynx, oropharynx and larynx are known collectively as mouth and oral cancers. Of these, cancers of the lip and oral cavity are the most common, with more than 377,700 cases worldwide in 2020. (GLOBOCAN). In India, the common leading cancer [....] » Read More
Epigenetic alterations play an important part in carcinogenesis. Different biological responses, including cell proliferation, migration, apoptosis, invasion, and senescence, are affected by epigenetic alterations in cancer. In addition, growth factors, such as transforming growt [....] » Read More
Despite important advances in the management of tumors in recent decades, glioblastoma (GBM) remains one of the deadliest human cancers. In fact, GBM presents the lowest median observed survival of all primary malignant brain and other CNS tumors (8 months). This poor prognosis i [....] » Read More
MicroRNAs have shown its role in cell proliferation, apoptosis and pathogenesis of acute lymphoblastic leukemia (ALL). Current diagnosis of ALL comprises invasive and inconvenient procedures including bone marrow biopsy. In spite of recent advancements in the treatment of ALL, st [....] » Read More
Tetraspanin proteins cross the membrane four times and span the cell surface to form two extracellular loops (EC1 and EC2) and one small intracellular loop, and typically short cytoplasmic N- and C-termini. They are involved in many biological pathways such as viral, bacterial, a [....] » Read More
Long non-coding RNAs (lncRNAs) are widely known for their various functions in cancer from tumor initiation to tumor progression and metastasis. Gliomas are the most prevalent primary forms of brain tumor, classified into grades I to IV according to their malignant histological f [....] » Read More
Vulvar cancer is a rare gynecological malignancy with incidence rates steadily increasing over the past 10 years. Despite aggressive treatment, recurrent disease is common. The goal of this case report is to give an overview of the techniques for interstitial brachytherapy [....] » Read More
Breast cancer metastasis is a continued concern for patients with recent development in our understanding of disease progression. In this paper, we highlight the pathophysiology behind breast cancer metastasis. Blood brain barrier disruption plays a critical component in progress [....] » Read More
There is an increased interest in alternative treatments that reduce the toxicity of chemotherapy by lowering the drug concentration, whilst maintaining potency against cancer cells. Previous studies have demonstrated that arabinoxylan from rice bran, MGN3/Biobran, sensitizes hum [....] » Read More
FAM46C is an oncosuppressor gene which is found mutated in approximately 10% of multiple myeloma (MM) patients. Recently, we proposed a model to explain FAM46C mode of action in MM. In highly-secreting MM cells, FAM46C regulates intracellular trafficking and protein secretion dyn [....] » Read More
Title : Digital profiling of protein and microRNA in Rhabdomyosarcoma
Atif A Ahmed, University of Washington-Seattle Children’s Hospital, United States
Rhabdomyosarcoma exhibits a complex prognostic algorithm based on histologic, biologic and clinical parameters. In contrast to alveolar rhabdomyosarcoma, embryonal (ERMS) and spindle cell and sclerosing rhabdomyosarcoma (SRMS) histologic types exhibit more heterogenous molecular [....] » Read More
Title : Low angle X - ray fiber diffraction wins gold for Cancer diagnosis
Veronica James, Australian National University, Australia
Every cancer sends out a type-specific signal, as soon as it starts, thus providing the earliest possible diagnosis of the cancer by the cancer itself. These signals can be detected as specific alterations in the low angle X-ray diffraction patterns for skin and/or hair. In [....] » Read More
Title : Electrochemical point-of-care sensor for early diagnosis of Ovarian Cancer
Michael Thompson, University of Toronto, Canada
Ovarian cancer (OC), the most lethal gynecological cancer, globally causes 150,000 deaths, annually. Notably, the 5-year survival rate is generally accepted to be over 90% if the disease is detected at Stage 1. The well-known currentCA-125diagnostictestforOChasbeenshowntoyieldbot [....] » Read More
Title : RNA m6A landscape reveals strong regulatability of tumor suppressor expression
Kaifu Chen, Harvard Medical School Country, United States
Cancer genes were known to display unique epigenetic features on chromatin of benign cells. Investigations into these features are making it increasingly clear that cancer genes differ from other genes regarding the mechanisms regulating their transcription. It is yet unknown whe [....] » Read More
Title : Targeting the ribosomes to treat blood cancers
Jian Kang, Peter MacCallum Cancer Centre, Australia
The majority of human tumors are characterized by deregulated signaling through the PI3K/RAS/MYC oncogenic network, leading to an increased rate of ribosome synthesis, mRNA translation and hence protein synthesis. Direct targeting of elevated ribosome biogenesis is becoming a new [....] » Read More
Title : The research on anti-tumor activity and its mechanism of traditional Chinese medicine Inonotus hispidus
Haiying Bao, Jilin Agricultural University, China
The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for a long history in China. I. hispidus mushroom mainly grows on five different tree species (Morus alba L., Ulmus macrocarpa Hance, [....] » Read More
Title : Targeting HTP1 ameliorates chemoresistance of Colorectal Cancer
Xiaofeng Liu, Peking University Cancer Hospital & Institute, China
Cancer stem cell (CSC)-related chemoresistance frequently causes poor prognosis of the patients with colorectal cancer (CRC). The discovery of the chemoresistance-relevant molecules and elucidation of the underlying mechanisms will provide potential therapeutic clues for CRC. In [....] » Read More
Title : Investigating the role of angiogenesis in chemoresistance - The example of API-5
Melanie Di Benedetto, University of Paris, France
Chemoresistance is a complex phenomenon involving intracellular as well as extracellular mechanisms that needs further studies. Among them, cell death inhibition or environmental cells (fibroblast or endothelial cells) interaction are still under studies. Anti-apoptotic pro [....] » Read More
Title : Immuno suppressive mediators impair pro inflammatory innate lymphoid cell function in human malignant Melanoma
Giuseppe Ercolano, University of Naples Federico II, Italy
Innate lymphoid cells (ILC) are a family of immune cells that are emerging as potent orchestrators of immune responses. In cancer, ILCs display both pro- and antitumorigenic functions depending on the nature of the tumor and the involved ILC subset. Little is known about the ILC& [....] » Read More
Title : Identification of gene-specific signatures associated with AGR2 expression and TGF-? exposure in Lung Cancer cellular model
Andrea Martisova, Masaryk University, Czech Republic
Epithelial to mesenchymal transition (EMT) is one of the key processes in tumour progression and metastasis development. TGF-β signaling plays an important role in this process, and through a cascade of signaling events, it enhances the transcription of EMT drivers. Recently [....] » Read More
Title : Carbohydrate loading: what science brings innovative to surgical oncology patients?
Luis Filipe de Oliveira Figliolino, University of Mogi das Cruzes, Brazil
Hospital services have increasingly sought the satisfaction of their clients, through which we are able to measure the quality of health care, as well as other measures of behavioral outcomes of patients1. It is believed to have a direct relationship between the degree of satisfa [....] » Read More
Title : Outlining the synergistic effects of combining Metformin and Simvastatin in ovarian cancer cells
Sara Mikhael, Saint-Joseph University, Lebanon
Improving response rates in Ovarian cancer is an urgent clinical issue. Drug repurposing offers a safe and a relatively fast alternative to the conventional methods for oncological drug discovery. Both, metformin, a biguanide approved to treat diabetes, and simvastatin, an HMG-Co [....] » Read More
Title : Jak 2 negative Polycythemia vera in tertiary care center in west up population in India : A rare presentation of 3 cases
Neema Tiwari, Swami Vivekanand Subharti University, India
Polycythaemia vera (PV) belongs to the group of myeloproliferative neoplasms with excessive increase in hemoglobin levels. They are clinically characterized by nonspecific symptoms such as fatigability, pruritus, early satiety due to splenomegaly, increased risk of infections, an [....] » Read More
Title : Tamoxifen : Contraceptive pill to anti-cancer drug
Soumik Laha, Bengal College of Pharmaceutical Sciences & Research, India
Tamoxifen, an anticancer drug which acts by competitive binding to estrogen receptor by blocking G1 phase of cell cycle to slow cell proliferation by reduction of transcription of estrogen regulated genes. Tamoxifen which was synthesized in 1962 and first discovered as compoun [....] » Read More
Title : Lymphatic drainage of breast : Clinicoanatomical perspective in Carcinoma breast
Shivi Mudgal nee Goel, Shivi Mudgal nee Goel Sri Ram Murti Smarak Institute of Medical Sciences, India
One of the most frequent types of neoplastic diseases in females worldwide is breast cancer resulting in significant morbidity and mortality. The commonest route of spread of breast tumor cells is via lymphatics and blood. We as anatomists would like to impress upon the lymphatic [....] » Read More
Title : Awareness of Oral Cancer in a community of Sunsari, Nepal: Oral Cancer awareness saves lives
Punam Kumari Mandal, Tribhuvan University, Nepal
One of the most prevalent cancers in the world, oral cancer is also one of the leading causes of mortality in some areas, such as South-Central Asia, and is a significant public health issue. Oral cancer is the third most prevalent cancer in women and the most common cancer [....] » Read More
Title : Feasibility of MicroRNAs profiling among Breast Cancer tissues at a sub Saharan University,Teaching Hospital Facility, Uganda.
Timothy Makumbi Kabanda, Makerere University Kampala, Uganda
The incidence of this early onset breast cancer in Uganda has tripled if compared to levels of 1961.Breast cancer in these women is peculiar in its progression and aggressiveness yet hardly an answer has been offered for those characteristics. The ray of hope has emerged through [....] » Read More
Title : Pharmacovigilance in multiple Myeloma care in sub-Saharan Africa
Ogbonna Collins Nwabuko, University of Calabar, Nigeria
The quality and disability adjusted life-years are the two predictive markers of average life expectancy of any patient. In Multiple myeloma (MM), the duos are the functions of the stage of presentation of primary disease and the impact of the therapeutic (anti-myeloma) intervent [....] » Read More
Title : Evolution of androgen deprivation in the treatment of Prostate Cancer in Kinshasa DRC
Dieudonne Molamba Moningo, University of Kinshasa, Congo
Objective: Prostate cancer (PCa) is hormone-dependent cancer. In our area, most patients often arrive at the locally advanced stage or the metastatic stage. This justifies the choice of androgen deprivation as the mode of treatment. The objective of this study was to describe the [....] » Read More
Title : The direct and indirect effects of affluence on survival in colon cancer : A population-Based study
Rosie Dew, University of Sunderland, United Kingdom
Background: Colorectal cancer is the fourth most common cancer in the UK. Socio-economic disparities are apparent in colorectal cancer survival in the UK and elsewhere. However, it is not known whether socio-economic status has a direct influence on survival or whether [....] » Read More
Title : BIOBRAN MGN-3; Effect of reducing side effects of chemotherapy in breast cancer patients
Dan Kenner, ImunoBran Luxembourg and France, France
The aim of study was to assess the effect of Biobran in reducing of chemotherapy induced side effects in terms of tiredness, anorexia, vomiting and hair loss and quality of life in terms of weight loss. Setting: Radiotherapy Department, Nishtar Hospital Multan. Material and Meth [....] » Read More
Title : Polymorphism in Thymidylate Synthase gene predicts survival and toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy
Parul Sharma, Thapar Institute of Engineering and Technology, India
Lung cancer is one of the most widely reported tumors having high morbidity and mortality rates with an estimated 1.8 million fatalities. Thymidylate synthase (TS) is an important target for chemotherapy treatments and platinum-based therapies since it is the cell's only [....] » Read More
Title : Effects of carbogen-Nicotinamide inhalation and r-Chop chemotherapy on p53 levels in DLBCL patients
Djoko Agung Priyambodo, Sebelas Maret University, Indonesia
Introduction Inhalation of carbogen (95% oxygen / 5% carbon dioxide) and nicotinamide is said to improve intratumor oxygenation and improve post-therapy outcomes (radiotherapy and chemotherapy). This is evidenced in cancer patients who obtained improvements in gradient recalled e [....] » Read More