Dan Kenner

Title : Modified Arabinoxylan from rice bran, MGN-3 / Biobran / ImunoBran, sensitizes metastatic Breast Cancer cells to Paclitaxel In Vitro,

Abstract:

There is an increased interest in alternative treatments that reduce the toxicity of chemotherapy by lowering the drug concentration, whilst maintaining potency against cancer cells. Previous studies have demonstrated that arabinoxylan from rice bran, MGN3/Biobran, sensitizes human breast cancer cells (BCC) to daunorubicin (DNR). In the present study, we further evaluated the ability of MGN-3 to sensitize cells to another chemotherapy agent, paclitaxel. Materials and Methods: Nonmetastatic MCF-7 (human BCC) and metastatic 4T1 (murine BCC) cells were cultured with different concentrations of paclitaxel in the presence or absence of MGN-3. Cell survival, DNA damage, and cell proliferation were examined. Results: MGN-3 increased the susceptibility of both types of cancer cells to paclitaxel by over 100-fold. Mechanistically, MGN-3 works synergistically with paclitaxel by causing DNA damage, enhancing apoptosis, and inhibiting cell proliferation in 4T1 cells. Conclusion: Our data demonstrate that MGN-3 is an effective chemosensitizer and may represent a novel adjuvant for the treatment of metastatic breast cancer.

Biography:

DAN KENNER, Ph.D., L.Ac graduated in 1979 from the Meiji College of Oriental Medicine in Japan, passed the Japanese National Licensing Examination and then trained in Internships at Osaka Medical University
Pain Clinic and Kinki University Medical Teaching Hospital. He is licensed to practice Oriental Medicine both in the U.S. and in Japan. He also has a Ph.D. in Naturopathic Medical Science from the First National University of Naturopathic Medical Sciences. Dr. Kenner is on the Board of Directors of the Acupuncture and Integrative Medicine College in Berkeley, California and the National Health Federation. He is author of The Whole-Body Workbook for Cancer and other titles. Since 1983, he has endeavoured to integrate the Naturopathic Medical Traditions of North America and Europe with the Traditional Medicine of East Asia.