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International Cancer Research Conference

March 24-26, 2025 | Singapore

March 24 -26, 2025 | Singapore
ICC 2022

Haiying Bao

Speaker at Cancer Conference 2022 - Haiying Bao
Jilin Agricultural University, China
Title : The research on anti-tumor activity and its mechanism of traditional Chinese medicine Inonotus hispidus

Abstract:

The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for a long history in China. I. hispidus mushroom mainly grows on five different tree species (Morus alba L., Ulmus macrocarpa Hance, Fraxinus mandshurica Rupr., Ziziphus jujuba Mill., and Malus pumila Mill.), and their fruiting bodies were all separately used in the market. To discuss the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics. We found that I. hispidus petroleum ether extract (IPE) has significant anti-tumor activity. Moreover, we explored the potential antitumor regulatory pathways and targets of I. hispidus, and performed whole transcriptome and proteome analyses in the H22 tumor-bearing mice model.The combined omics analysis revealed five key genes/proteins, including Lilrb4aNrp1GzmaGstt1 and Pdk4, which may play a role in the anti-tumor pathway and were validated.

 

Biography:

Dr. Bao working in the College of Chinese Materia Medica, Jilin Agricultural University. From 1993 to 1996, she studied for a master's degree in Changchun College of Traditional Chinese Medicine(Chinese materia medica), get a Master of Medicine. From 1998 to 2001, she studied for doctor's degree in Jilin Agricultural University(The direction of medicinal fungi), earn a doctorate in agronomy, exceptional promotion to professor in 2003. From 2004 to 2005 Postdoctoral fellow at the School of Pharmacy, Chungnam National University, South Korea(Natural Medicinal Chemistry and Molecular Pharmacology).

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