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International Cancer Research Conference

March 24-26, 2025 | Singapore

March 24 -26, 2025 | Singapore
ICC 2022

George Zachos

Speaker at Cancer Conference 2022 - George Zachos
University of Crete, Greece
Title : The abscission checkpoint: a protector of chromosomal stability

Abstract:

Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.

Biography:

George Zachos completed his PhD at the University of Crete and received postdoctoral training at the Beatson Institute for Cancer Research, Glasgow, U.K. investigating DNA damage checkpoint mechanisms. In 2008, he moved to the Department of Biology of the University of Crete in Greece as an Assistant Professor in Cell Biology, became Associate Professor in 2015 and continues to hold this position today. Discoveries from the Zachos lab have identified novel mechanisms of the mitotic spindle and abscission checkpoints during cell division in human cells. He has published 39 papers in leading scientific journals and has received  >2000 citations.

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