Theranostic nanoparticles combined particle therapy

Title : Theranostic nanoparticles combined particle therapy

Abstract:

The challenge of radiotherapy is to increase radiation damage on tumor whilst preserving healthy tissue. Particle therapy offers an alternative method whose ballistic properties improve tumor targeting. However the development of this radiation molality is limited by the impact on the healthy tissues irradiated at the entrance of beam in the body. This work aims to enhance particle therapy’s performance by adding radioenhancing nanoparticles (REN) that amplify ionizing radiation effects at the target where they concentrate. After a state-of -the-art of the current developments on NP-radiation combined protocols, the first results obtained by the team on human cells spheroids will be presented.

It includes internalization and localization of the REN in the cells and their effect on cell survival treated by medical Carbon ion beam (290 MeV/uma) with or without REN.

To understand how PtNPs interact with biomolecules to induce radio-enhancement, this study investigates the combined effect of PtNPs and ion irradiation on cell proliferation and DNA double-strand break (DSB) repair in tumor spheroids.

Biography:

Sandrine Lacombe, after a PhD in chemical-physics, she conducted early research at the Fritz Haber Institute of the Max Planck Society under Nobel Laureate Professor G. Ertl. She later served as invited professor at the Sherbrooke University Hospital (Canada) and received an International Research Collaboration Award from the University of Sydney (Australia). Her research focuses on advancing particle therapy using theranostic nanoparticles. She contributed to 93 publications, supervised 11 PhDs. She currently direct the interdisciplinary center for innovative radiation therapies, iNanoTheRad. Former Vice-President for International Affairs of U.Paris-Saclay, she also offer her expertise to other institutions for the development of international and European strategies.