Platinum micromotors for mucosal penetration and colorectal cancer therapy

Title : Platinum micromotors for mucosal penetration and colorectal cancer therapy

Abstract:

The therapeutic outcomes of medications were restricted by the colonic mucosal barrier during the treatment of colorectal cancer (CRC). Micro/nanomotors can overcome the mucus barriers to reach deep colorectal tumors. In this study, we constructed a novel microsized PLGA-Pt micromotor (MM) driven by hydrogen peroxide (H₂O₂ ) to enhance drug delivery to the CRC tissues and achieve effective antitumor therapy. The PLGA-Pt MMs actively traversed the colonic mucosal barrier with the assist of gas propulsion, while continuously releasing Pt 2⁺ ions within the tumor microenvironment. In vitro studies revealed that the PLGA-Pt MMs exhibited rapid movement in the presence of H₂O₂  , achieving superior colonic mucosal penetration. It effectively delivered Pt 2+ ions to the nuclei, forming DNA-Pt adducts that induced significant DNA damage and apoptosis of CRC cells. In vivo studies showed the PLGA-Pt MM significantly suppressed orthotopic tumor growth and activated antitumor immunity, enhancing the therapeutic effect against CRC. This study presents a micromotor capable of overcoming mucosal barriers for efficient treatment of orthotopic CRC.

Keywords: Colonic mucosal penetration； PLGA-Pt micromotor； H2O2-driven； Colorectal cancer.

Biography:

Dr. Zhang is a medical doctor with a Ph.D., specializing in individualized treatment strategies for digestive system tumors. Clinically, his core focus lies in establishing a comprehensive diagnosis and treatment system that integrates chemotherapy, targeted immunotherapy, and minimally invasive interventional therapies. Dr. Zhang has published multiple SCI papers in journals such as International Journal of Oncology, Shock, Cancer Medicine, and International Journal of Pharmaceutics. Through these works, Dr. Zhang has advanced understanding of liver cancer stem cell biology, identified critical illness biomarkers, and developed image guided HIFU ablation strategies, demonstrating a strong commitment to translational research that bridges basic science and clinical oncology.