Title : In search of common path in cancerous point mutations
Abstract:
The proliferative biophysical structure is associated with Earth’s or Lunar time(183 or 777), Earth’s gravity(734) and Lunar gravity(0.1605 or 705) in context of 900-109 fundamental mathematical complex with a directional difference of 1. The Histidine(155.1552)-Tyrosine(181.1894) structural complex is associated with cancer biology where core values(Cv) of tyrosine = 181*0.0019 – 0.1894 = 0.1545 or 645 = 900 – 255 according to the formula Time = M*0.0019 derived from 14.0267, an inter-amino acid factor and M is the integer mass can be transformed into time. Towards evaluation of mutational values in cancerous point mutations core values are important.
Considering histidine structure, 559 – 155 = 404 or 319 where 31*13 = 403 with a directional difference of 1. Histidine possesses a bisectional infrastructure where 0.1552 or 652*2 = 1304 or404(under suppression) and 248*2 = 496 where 559 + 496 = 1055 or 155 and 403 – 319 = 84 = 652 – 568(i.e. 734*2) and 248 - 84 = 164 = 155(i.e. 84 + 71) + 9(factor of directional change) and correspondingly 652 – 171(9) = 481 and 248+ 171 = 419 = 900 – 481 in the structure. In reverse, 403 + 319 = 722 = 900 – 178 where 568 + 510(i.e. 705*2) = 1078 or 178. The tyrosine crucial structures, 900 = 645 + 255 = 289(i.e. 1894 – 1605 = 289) + 611 shows 322(neutral point) – 154 = 168 where 390 – 322 = 68 = 58 + 10(i.e. 99 + 10 = 109) and where 958 = 390 + 568(i.e. 510 + 58) and correspondingly 361(limitation and neutralization) + 58 = 419 and 178 + 5(i.e.183*2 – 361) = 183 in the structure. A reverse action is found where 58(beyond 900) + 109 = 167 = 99(reverse factor) + 68 where 223(reverse of 322) – 68 = 155.
A blocking of oxy-time(329 or 239) has been found in the system towards mutation. Oxy-therapy might be a process in cancer treatment needed investigations. Mathematically, 329 -155 = 174 = 68 + 106(would be influx of electro-gravitational impulses towards proliferation) or 223(reverse of 322) + 106 = 329 in the structure. It is seen 155 + 84 = 239 and correspondingly 652 + 84 = 736 = 32*23 and 248 – 84 = 164.
In JAK2 G1849T V617F or TP53 G469T V157F, the mutational values 151(G) – 126(T) = 25 or 0.0475 and 754(Val Cv) – 1235(Phe Cv) = - 0.0481 or 481(120) = 900 – 419 where 41*14 = 574(reverse of 475), avoiding decimals and negative mark. It is seen 481 + 93 = 574 and 419 + 574 = 993 where 109 + 93 = 202 = 404/2 and 539(i.e. 734 + 705 = 1439 or 539) + 481 = 1020 or 120 and 539(i.e. 512 + 27) + 419 = 958 and 167 + 120 = 287 = 574/2 in the structure. A reverse action has been found in the system where 778 – 419 = 359 and 778 + 419 = 1197 or 297 = 481 – 184.
In EGFR lung cancer mutations, L858R and C797S are two anti-parallel mutations that shows 1289(R Cv) – 753(L Cv) = 536 and 1065(S Cv) – 709(C Cv) = 356 where 536 + 3 = 539 and 356 + 3 = 359 and where 539 – 359 = 180 = 183 – 3 that compatible to the histidine-tyrosine complex where 248 + 180 = 428 = 322 + 106 and 248 – 180 = 68 = 174 – 106 where 174 + 155 = 329. Again, 559 + 180 = 739 = 736 + 3 and 559 – 180 = 379 = 382(reverse of 183) – 3 and correspondingly 778(reverse of 777 differentiated by 1) + 180 = 958 and also 403 – 180 = 223 = 329 – 106(would be influx of electro-gravitational impulses).