In search of common path in cancerous point mutations

Title : In search of common path in cancerous point mutations

Abstract:

The proliferative biophysical structure is associated with Earth’s or Lunar time(183 or 777), Earth’s gravity(734) and Lunar gravity(0.1605 or 705) in context of 900-109 fundamental mathematical complex with a directional difference of 1. The Histidine(155.1552)-Tyrosine(181.1894) structural complex is associated with cancer biology where core values(C_v) of tyrosine = 181*0.0019 – 0.1894 = 0.1545 or 645 = 900 – 255 according to the formula Time = M*0.0019 derived from 14.0267, an inter-amino acid factor and M is the integer mass can be transformed into time. Towards evaluation of mutational values in cancerous point mutations core values are important.

Considering histidine structure, 559 – 155 = 404 or 319 where 31*13 = 403 with a directional difference of 1. Histidine possesses a bisectional infrastructure where 0.1552 or 652*2 = 1304 or404(under suppression) and 248*2 = 496 where 559 + 496 = 1055 or 155 and 403 – 319 = 84 = 652 – 568(i.e. 734*2) and 248 - 84 = 164 = 155(i.e. 84 + 71) + 9(factor of directional change) and correspondingly 652 – 171(9) = 481 and 248+ 171 = 419 = 900 – 481 in the structure. In reverse, 403 + 319 = 722 = 900 – 178 where 568 + 510(i.e. 705*2) = 1078 or 178. The tyrosine crucial structures, 900 = 645 + 255 = 289(i.e. 1894 – 1605 = 289) + 611 shows 322(neutral point) – 154 = 168 where 390 – 322 = 68 = 58 + 10(i.e. 99 + 10 = 109) and where 958 = 390 + 568(i.e. 510 + 58) and correspondingly 361(limitation and neutralization) + 58 = 419 and 178 + 5(i.e.183*2 – 361) = 183 in the structure. A reverse action is found where 58(beyond 900) + 109 = 167 = 99(reverse factor) + 68 where 223(reverse of 322) – 68 = 155.

A blocking of oxy-time(329 or 239) has been found in the system towards mutation. Oxy-therapy might be a process in cancer treatment needed investigations. Mathematically, 329 -155 = 174 = 68 + 106(would be influx of electro-gravitational impulses towards proliferation) or 223(reverse of 322) + 106 = 329 in the structure. It is seen 155 + 84 = 239 and correspondingly 652 + 84 = 736 = 32*23 and 248 – 84 = 164.

In JAK2 G1849T V617F or TP53 G469T V157F, the mutational values 151(G) – 126(T) = 25 or 0.0475 and 754(Val C_v) – 1235(Phe C_v) = - 0.0481 or 481(120) = 900 – 419 where 41*14 = 574(reverse of 475), avoiding decimals and negative mark. It is seen 481 + 93 = 574 and 419 + 574 = 993 where 109 + 93 = 202 = 404/2 and 539(i.e. 734 + 705 = 1439 or 539) + 481 = 1020 or 120 and 539(i.e. 512 + 27) + 419 = 958 and 167 + 120 = 287 = 574/2 in the structure. A reverse action has been found in the system where 778 – 419 = 359 and 778 + 419 = 1197 or 297 = 481 – 184.

In EGFR lung cancer mutations, L858R and C797S are two anti-parallel mutations that shows 1289(R C_v) – 753(L C_v) = 536 and 1065(S C_v) – 709(C C_v) = 356 where 536 + 3 = 539 and 356 + 3 = 359 and where 539 – 359 = 180 = 183 – 3 that compatible to the histidine-tyrosine complex where 248 + 180 = 428 = 322 + 106 and 248 – 180 = 68 = 174 – 106 where 174 + 155 = 329. Again, 559 + 180 = 739 = 736 + 3 and 559 – 180 = 379 = 382(reverse of 183) – 3 and correspondingly 778(reverse of 777 differentiated by 1) + 180 = 958 and also 403 – 180 = 223 = 329 – 106(would be influx of electro-gravitational impulses).

Biography:

Ratan Kumar Sarkar graduated with a B.Sc. from the University of Calcutta and has published over twenty research papers in Scientific and Academic Publishing journals. He also participated in the International Cancer Research Conference 2025, contributing to global discussions on cutting-edge developments in cancer research.