Title : Molecular diagnostic and therapeutic potentials for cancer recurrence
Abstract:
After the initial treatment is completed, the fear of cancer recurrence is the main concern for cancer survivors. Indeed, recurrence is the key threat to survival. The identification of recurrence-related genetic alterations in cancer patients may help better stratify high-risk individuals and guide treatment strategies. Targeted therapy is a common treatment modality for cancer. Nevertheless, drug resistance is a major cause of therapeutic failure which leading to tumor recurrence and disease progression. The personalized prediction of therapeutic resistance, recurrence, or metastatic disease progression remains an unsolved problem. Our previous studies attempted to identify the molecular biomarkers of recurrence and drug resistance in several cancers. Besides, we also tried to find the biomarkers and therapeutic targets that play critical roles in tumorigenesis.
In this presentation, I would like to share my studies on the identification of genetic alterations in recurrence and the plausible mechanism(s) involving in resistance and recurrence, finally, end up with some studies on the treatment of cancer.
